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广泛耐药结核病，巴基斯坦。

Extensively drug-resistant tuberculosis, Pakistan.

机构信息

Department of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan.

出版信息

Emerg Infect Dis. 2010 Sep;16(9):1473-5. doi: 10.3201/eid1609.100280.

DOI:10.3201/eid1609.100280
PMID:20735937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3294979/
Abstract

Frequency of extensively drug-resistant tuberculosis in Pakistan increased from 1.5% in 2006 to 4.5% in 2009 (p<0.01). To understand the epidemiology, we genotyped selected strains by using spoligotyping, mycobacterial interspersed repetitive units-variable number of tandem repeats, and IS6110 restriction fragment length polymorphism analysis.

摘要

巴基斯坦广泛耐药结核病的发病率从 2006 年的 1.5%上升至 2009 年的 4.5%（p<0.01）。为了了解其流行病学特征，我们采用 spoligotyping、分枝杆菌间隔重复单元-可变数串联重复和 IS6110 限制片段长度多态性分析对选定的菌株进行了基因分型。

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本文引用的文献

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Epidemiology of antituberculosis drug resistance 2002-07: an updated analysis of the Global Project on Anti-Tuberculosis Drug Resistance Surveillance.2002 - 2007年抗结核药物耐药性流行病学：全球抗结核药物耐药性监测项目的最新分析
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Trends in Mycobacterium tuberculosis resistance, Pakistan, 1990-2007.1990-2007 年巴基斯坦结核分枝杆菌耐药趋势。
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Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patterns.大序列多态性可对具有祖传间隔寡核苷酸分型模式的结核分枝杆菌菌株进行分类。
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