Warrington Primary Care Trust, Community Paediatric Audiology Services, Child Development Centre, Warrington, UK.
Clin Otolaryngol. 2010 Aug;35(4):291-9. doi: 10.1111/j.1749-4486.2010.02176.x.
To investigate the relationship between those issues concerning quality of life in patients with neurofibromatosis type 2 (NF2) as identified by the closed set NF2 questionnaire and the eight norm-based measures and the physical component summary (PCS) and mental component summary (MCS) scores of the Short Form-36 (SF-36) Questionnaire.
Postal questionnaire study.
Questionnaires sent to subjects' home addresses.
Eighty-seven adult subjects under the care of the Manchester Multidisciplinary NF2 Clinic were invited to participate.
Sixty-two (71%) completed sets of closed set NF2 questionnaires and SF-36 questionnaires were returned.
Subjects with NF2 scored less than the norm of 50 on both the physical component summary and mental component summary scores and the eight individual norm-based measures of the Short Form-36 questionnaire. Correlations (using Kendall's tau) were examined between patients' perceptions of their severity of difficulty with the following activities and the eight norm-based measures and the physical component summary and mental component summary scores of the Short Form-36 questionnaire: Communicating with spouse/significant other (N = 61). The correlation coefficients were significant at the 0.01 level for the mental component summary score, together with three of the norm-based scores [vitality (VT), social functioning and role emotional]. Social communication (N = 62). All 10 correlations were significant at the 0.01 or 0.001 level. Balance (N = 59). All 10 correlations were highly significant at the P < 0.001 level. Hearing difficulties (N = 61). All correlations were significant at either the 0.01 level or less apart from the mental component summary score and three of the norm-based scores (role physical, VT and mental health). Mood change (N = 61). All correlations were significant at the 0.01 level or less, apart from one norm-based score (role physical).
The Short Form-36 questionnaire has allowed us to relate patients' perceptions of their difficulties, as identified by the closed set NF2 questionnaire, to the physical and mental domains measured by this validated and widely used scale, and has provided further insight into areas of functioning affected by NF2.
研究 2 型神经纤维瘤病（NF2）患者封闭式 NF2 问卷确定的生活质量问题与基于常模的八项测量指标以及健康调查简表（SF-36）的身体成分综合评分（PCS）和精神成分综合评分（MCS）之间的关系。
邮寄问卷研究。
问卷寄送至患者的家庭住址。
邀请了 87 名在曼彻斯特多学科 NF2 诊所接受治疗的成年患者参与研究。
62 名（71%）患者完成了封闭式 NF2 问卷和 SF-36 问卷的填写并将其寄回。
NF2 患者的 PCS 和 MCS 评分均低于 50 分，低于基于常模的八项 SF-36 问卷单项评分。使用 Kendall's tau 检验患者对以下各项活动困难程度的感知与基于常模的八项测量指标以及 SF-36 的 PCS 和 MCS 评分之间的相关性：与配偶/重要他人交流（N = 61）。精神成分综合评分与 3 项基于常模的评分[活力（VT）、社会功能和角色情绪]具有显著相关性（P < 0.01）。社会交流（N = 62）。10 项相关性均具有统计学意义（P < 0.01 或 P < 0.001）。平衡能力（N = 59）。10 项相关性均具有显著统计学意义（P < 0.001）。听力障碍（N = 61）。除精神成分综合评分和 3 项基于常模的评分（身体角色、VT 和心理健康）外，所有相关性均具有统计学意义（P < 0.01 或 P < 0.001）。情绪变化（N = 61）。除身体角色评分外，所有相关性均具有统计学意义（P < 0.01 或 P < 0.001）。
SF-36 问卷使我们能够将患者对封闭式 NF2 问卷确定的困难的感知与该经验证和广泛使用的量表所测量的身体和精神领域相关联，并进一步深入了解 NF2 影响的功能领域。
