中国不同省份结核分枝杆菌的 spoligotypes。
Spoligotypes of Mycobacterium tuberculosis from different Provinces of China.
机构信息
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Beijing, China.
出版信息
J Clin Microbiol. 2010 Nov;48(11):4102-6. doi: 10.1128/JCM.00549-10. Epub 2010 Aug 25.
Abstract
A total of 2,346 Mycobacterium tuberculosis isolates from 13 provinces in China were genotyped by spoligotyping. Two hundred seventy-eight spoligotypes were identified: 2,153 isolates were grouped into 85 clusters, and the remaining 193 isolates were orphans. Comparison with the SpolDB4.0 database revealed that 118 spoligotypes had shared international type numbers in the database and the other 160 were novel. These 160 novel spoligotypes were assigned to families and subfamilies using the SpotClust program. The most prevalent family was the Beijing family (74.08%), followed by the T family (14.11%). CAS family strains were found only in the Xinjiang and Tibet regions, while EAI family strains were found only in Fujian Province. In conclusion, the present study of the M. tuberculosis population in China demonstrated that Beijing family isolates are the most prevalent strains in China and that they exhibit geographical variation. Furthermore, many new spoligotypes were found in this study.
摘要
对来自中国 13 个省份的 2346 株结核分枝杆菌分离株进行 spoligotyping 基因分型。鉴定出 278 种 spoligotype：2153 株分离株分为 85 个克隆群，其余 193 株为孤儿。与 SpolDB4.0 数据库比较显示，118 种 spoligotype 在数据库中具有共同的国际类型编号，其余 160 种为新的 spoligotype。使用 SpotClust 程序将这 160 种新的 spoligotype 分配到家族和亚家族。最常见的家族是北京家族（74.08%），其次是 T 家族（14.11%）。CAS 家族菌株仅在新疆和西藏地区发现，而 EAI 家族菌株仅在福建省发现。总之，本研究表明中国结核分枝杆菌种群中，北京家族分离株是中国最常见的菌株，具有地理变异。此外，本研究还发现了许多新的 spoligotype。
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