当前关于卵泡刺激素受体基因调控的概念。
Current concepts of follicle-stimulating hormone receptor gene regulation.
机构信息
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
出版信息
Biol Reprod. 2011 Jan;84(1):7-17. doi: 10.1095/biolreprod.110.085043. Epub 2010 Aug 25.
Abstract
Follicle-stimulating hormone (FSH), a pituitary glycoprotein hormone, is an integral component of the endocrine axis that regulates gonadal function and fertility. To transmit its signal, FSH must bind to its receptor (FSHR) located on Sertoli cells of the testis and granulosa cells of the ovary. Thus, both the magnitude and the target of hormone response are controlled by mechanisms that determine FSHR levels and cell-specific expression, which are supported by transcription of its gene. The present review examines the status of FSHR/Fshr gene regulation, emphasizing the importance of distal sequences in FSHR/Fshr transcription, new insights gained from the influx of genomics data and bioinformatics, and emerging trends that offer direction in deciphering the FSHR/Fshr regulatory landscape.
摘要
卵泡刺激素（FSH），一种垂体糖蛋白激素，是调节性腺功能和生育能力的内分泌轴的一个组成部分。为了传递其信号，FSH 必须与位于睾丸的支持细胞和卵巢的颗粒细胞上的受体（FSHR）结合。因此，激素反应的幅度和靶标都受到决定 FSHR 水平和细胞特异性表达的机制的控制，这些机制得到其基因转录的支持。本综述检查了 FSHR/Fshr 基因调控的现状，强调了远端序列在 FSHR/Fshr 转录中的重要性，从基因组学数据和生物信息学的涌入中获得的新见解，以及为破译 FSHR/Fshr 调控景观提供方向的新兴趋势。
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