人参皂苷的吸收、分布、排泄及代谢研究。V. 大鼠大肠中人参皂苷Rb2的分解产物

Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats.

作者信息

Karikura M, Miyase T, Tanizawa H, Takino Y, Taniyama T, Hayashi T

机构信息

School of Pharmaceutical Sciences, University of Shizuoka, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Oct;38(10):2859-61. doi: 10.1248/cpb.38.2859.

DOI:10.1248/cpb.38.2859

PMID:2076572

Abstract

The decomposition of ginsenoside Rb2 (Rb2) in the rat large intestine after oral administration was investigated in detail. A part of Rb2 was decomposed and six decomposition products (I-VI) were observed on thin-layer chromatogram. Among them, five products (I-V) were isolated, and identification of these compounds was done by carbon-13 nuclear magnetic resonance (13C-NMR). On the basis of 13C-NMR analysis, these compounds were identified as ginsenoside Rd (I), 3-O-beta-D-glucopyranosyl-20-O- [alpha-L-arabinopyranosyl(1----6)-beta-D-glucopyranosyl]-20(S)- proto-panaxadiol (II), ginsenoside F2 (III), 20-O-[alpha-L-arabinopyranosyl(1----6)-beta-D-glucopyranosyl]-20(S )- protopanaxadiol (IV), and compound K (V), respectively.

摘要

详细研究了人参皂苷Rb2（Rb2）口服给药后在大鼠大肠中的分解情况。一部分Rb2发生分解，在薄层色谱图上观察到六种分解产物（I - VI）。其中，分离出了五种产物（I - V），并通过碳 - 13核磁共振（13C - NMR）对这些化合物进行了鉴定。基于13C - NMR分析，这些化合物分别被鉴定为人参皂苷Rd（I）、3 - O - β - D - 吡喃葡萄糖基 - 20 - O - [α - L - 阿拉伯吡喃糖基（1→6）- β - D - 吡喃葡萄糖基] - 20（S）- 原人参二醇（II）、人参皂苷F2（III）、20 - O - [α - L - 阿拉伯吡喃糖基（1→6）- β - D - 吡喃葡萄糖基] - 20（S）- 原人参二醇（IV）和化合物K（V）。