Weizer Jennifer S, Goyal Anju, Ple-Plakon Patricia, Trzcinka Agnieszka, Strong Bradley D, Bruno Christina A, Junn Justin, Tseng Irene, Niziol Leslie M, Musch David C, Moroi Sayoko E
Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105, USA.
Ophthalmic Surg Lasers Imaging. 2010 Sep-Oct;41(5):532-7. doi: 10.3928/15428877-20100726-06. Epub 2010 Jul 29.
To study bleb morphology and positional intraocular pressure (IOP) change (IOP supine to IOP sitting).
In this observational case series, blebs were graded for height, extent, vascularity, microcysts, and "ring of steel." Positional IOP change was analyzed using the paired t test. Associations between IOP change and bleb morphologies were evaluated by regression adjusting for inter-eye dependency.
Ninety-five eyes of 68 subjects were included. Decreased bleb height (P = .05), absence of microcysts (P = .02), and increased bleb vascularity (P = .02) were associated with larger positional IOP change. Twenty patients with a filter in one eye and a medically treated fellow eye had larger positional IOP change in the medically treated eye (6.1 vs 4.6 mm Hg, respectively; P = .01).
Successful filtration surgery results in both lower IOP and less positional IOP change compared with medically treated eyes. Bleb features associated with smaller positional IOP change include higher elevation, microcysts, and less vascularity.
研究滤过泡形态及体位性眼压变化（仰卧位眼压至坐位眼压）。
在这个观察性病例系列中，对滤过泡的高度、范围、血管化程度、微囊肿及“钢环”进行分级。使用配对t检验分析体位性眼压变化。通过对眼间相关性进行回归分析来评估眼压变化与滤过泡形态之间的关联。
纳入68名受试者的95只眼。滤过泡高度降低（P = .05）、无微囊肿（P = .02）及滤过泡血管化程度增加（P = .02）与更大的体位性眼压变化相关。20名患者一只眼行滤过手术，另一只眼药物治疗，药物治疗眼的体位性眼压变化更大（分别为6.1与4.6 mmHg；P = .01）。
与药物治疗的眼相比，成功的滤过手术可使眼压降低且体位性眼压变化更小。与较小的体位性眼压变化相关的滤过泡特征包括更高的隆起、微囊肿及更少的血管化。
