甲醛与白血病：更新的荟萃分析及偏倚评估。
Formaldehyde and leukemia: an updated meta-analysis and evaluation of bias.
机构信息
Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, USA.
出版信息
J Occup Environ Med. 2010 Sep;52(9):878-86. doi: 10.1097/JOM.0b013e3181ef7e31.
OBJECTIVE
Formaldehyde exposures are common, and data linking these exposures to leukemia have been mixed and controversial. The objective of this analysis is to review the current epidemiologic literature on formaldehyde and leukemia.
METHODS
We performed an updated meta-analysis focusing on high-exposure groups and myeloid leukemia and included two large recent studies: one involving >25,000 workers in US formaldehyde industries and the other involving a cohort of >13,000 funeral directors and embalmers.
RESULTS
Formaldehyde was associated with increased risks of leukemia (relative risk = 1.53; 95% confidence interval = 1.11 to 2.21; P = 0.005; 14 studies), specifically myeloid leukemia (relative risk = 2.47; 95% confidence interval = 1.42 to 4.27; P = 0.001; 4 studies).
CONCLUSION
These findings provide evidence of increased myeloid leukemia risk with exposure to formaldehyde.
目的
甲醛暴露很常见，将这些暴露与白血病联系起来的数据一直存在争议。本分析的目的是回顾甲醛与白血病的当前流行病学文献。
方法
我们进行了一项更新的荟萃分析，重点关注高暴露人群和髓性白血病，并纳入了两项最近的大型研究：一项涉及美国甲醛行业的超过 25000 名工人，另一项涉及超过 13000 名殡仪馆馆长和防腐师的队列研究。
结果
甲醛与白血病风险增加相关（相对风险=1.53；95%置信区间=1.11 至 2.21；P=0.005；14 项研究），特别是髓性白血病（相对风险=2.47；95%置信区间=1.42 至 4.27；P=0.001；4 项研究）。
结论
这些发现提供了甲醛暴露与骨髓性白血病风险增加的证据。
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