State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan, P. R. China.
J Microbiol. 2010 Aug;48(4):438-44. doi: 10.1007/s12275-010-0048-3. Epub 2010 Aug 20.
3-O-alpha-D-ribofuranosyl epothilone A (epothiloneoside A) is a major component of glycosylated epothilones in Sorangium cellulosum strain So0157-2. The production and glycosylation ratios of epothiloneoside A in both solid and liquid culture conditions with various pH values and carbon sources were studied. The results showed that glycosylation occurs whenever epothilones are produced, regardless of changes in pH values, production time curves, and different carbon sources. We suggest that glycosylation is a stable process, paralleling the biosynthesis of epothilones in the So0157-2 strain.
3-O-α-D-呋喃核糖基埃坡霉素 A（埃坡霉素苷 A）是纤维堆囊菌 So0157-2 菌株中糖基化埃坡霉素的主要成分。本文研究了不同 pH 值和碳源条件下固体和液体培养条件下埃坡霉素苷 A 的产生和糖基化比率。结果表明，无论 pH 值变化、生产时间曲线和不同碳源如何，只要产生埃坡霉素就会发生糖基化。我们认为糖基化是一个稳定的过程，与 So0157-2 菌株中埃坡霉素的生物合成平行。
