Department of Bioengineering, University of California-Berkeley, UCSF/UCB Joint Graduate Group in Bioengineering, Berkeley Sensor & Actuator Center, Berkeley, CA, USA.
Curr Opin Biotechnol. 2010 Aug;21(4):489-97. doi: 10.1016/j.copbio.2010.06.012.
Free electrons in a noble metal nanoparticle can be resonantly excited, leading to their collective oscillation termed as a surface plasmon. These surface plasmons enable nanoparticles to absorb light, generate heat, transfer energy, and re-radiate incident photons. Creative designs of nanoplasmonic optical antennae (i.e. plasmon resonant nanoparticles) have become a new foundation of quantitative biology and nanomedicine. This review focuses on the recent developments in dual-functional nanoplasmonic optical antennae for label-free biosensors and nanoplasmonic gene switches. Nanoplasmonic optical antennae, functioning as biosensors to significantly enhance biochemical-specific spectral information via plasmon resonance energy transfer (PRET) and surface-enhanced Raman spectroscopy (SERS), are discussed. Nanoplasmonic optical antennae, functioning as nanoplasmonic gene switches to enable spatiotemporal regulation of genetic activity, are also reviewed. Nanoplasmonic molecular rulers and integrated photoacoustic-photothermal contrast agents are also described.
自由电子在贵金属纳米粒子中可以被共振激发，导致它们的集体振荡，称为表面等离激元。这些表面等离激元使纳米粒子能够吸收光、产生热、传递能量和重新辐射入射光子。纳米等离激元光学天线（即等离激元共振纳米粒子）的创造性设计已成为定量生物学和纳米医学的新基础。本综述重点介绍了用于无标记生物传感器和纳米等离激元基因开关的双功能纳米等离激元光学天线的最新进展。讨论了作为生物传感器的纳米等离激元光学天线，通过等离激元共振能量转移（PRET）和表面增强拉曼光谱（SERS）显著增强生化特异性光谱信息的功能。还回顾了作为纳米等离激元基因开关的纳米等离激元光学天线，使其能够时空调节遗传活性。纳米等离激元分子标尺和集成光声-光热对比剂也有所描述。
