NHLBI Proteomics Core, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892, USA.
Cardiovasc Res. 2010 Nov 1;88(2):211-8. doi: 10.1093/cvr/cvq277. Epub 2010 Aug 30.
This review will summarize proteomic methods that are useful in studying the role of mitochondria in cardioprotection. The strengths and weaknesses of some of the different approaches are discussed. We focus on the cardiac mitochondrial proteome with emphasis on changes associated with cell death and protection, and we summarize how proteomic data have contributed to addressing the role of mitochondria in cardioprotection.
这篇综述将总结蛋白质组学方法,这些方法在研究线粒体在心脏保护中的作用方面很有用。讨论了一些不同方法的优缺点。我们专注于心脏线粒体蛋白质组学,重点关注与细胞死亡和保护相关的变化,并总结了蛋白质组学数据如何有助于解决线粒体在心脏保护中的作用。