Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Free Radic Res. 2010 Nov;44(11):1296-303. doi: 10.3109/10715762.2010.500667.
A total of 267 clinically stable chronic obstructive pulmonary disease (COPD) patients provided complete data about diet and oxidative stress markers in order to assess the relationship between antioxidant rich food groups and nutrients, and serum markers of oxidative stress in COPD. Dietary data of the last 2 years was assessed using a validated food frequency questionnaire (122 items). Levels of carbonyls, nitrotyrosine, malondialdehyde and reduced glutathione (GSH) were measured in serum. Vitamin E intake was inversely associated with levels of carbonyls (p = 0.05) and olive oil was positively associated with GSH levels (p = 0.01), in active smokers. Intake of vegetables was related to a decrease of malondialdehyde levels (p = 0.04) in former smokers. No statistically significant associations were found between remaining dietary antioxidants and serum oxidative stress markers. These results provide new data for a potential dietary modulation of systemic oxidative stress in COPD patients, particularly in those that continue smoking.
共有 267 名临床稳定的慢性阻塞性肺疾病（COPD）患者提供了有关饮食和氧化应激标志物的完整数据，以评估富含抗氧化剂的食物组和 COPD 患者血清氧化应激标志物之间的关系。过去 2 年的饮食数据使用经过验证的食物频率问卷（122 项）进行评估。血清中羰基、硝基酪氨酸、丙二醛和还原型谷胱甘肽（GSH）的水平。维生素 E 的摄入量与羰基水平呈负相关（p = 0.05），橄榄油与 GSH 水平呈正相关（p = 0.01），在吸烟者中。蔬菜摄入量与前吸烟者丙二醛水平降低有关（p = 0.04）。其余饮食抗氧化剂与血清氧化应激标志物之间未发现统计学上显著关联。这些结果为 COPD 患者全身氧化应激的潜在饮食调节提供了新的数据，特别是在继续吸烟的患者中。
