Department of Population Health Research, Alberta Health Services, Calgary, Alberta, Canada.
Int J Obes (Lond). 2011 Mar;35(3):427-35. doi: 10.1038/ijo.2010.147. Epub 2010 Sep 7.
We examined the effects of an aerobic exercise intervention on adiposity outcomes that may be involved in the association between physical activity and breast cancer risk.
This study was a two-centre, two-armed, randomized controlled trial. The 1-year-long exercise intervention included 45 min of moderate-to-vigorous aerobic exercise five times per week, with at least three of the sessions being facility based. The control group was asked not to change their activity and both groups were asked not to change their diet.
A total of 320 postmenopausal, sedentary, normal weight-to-obese women aged 50-74 years who were cancer-free, nondiabetic and nonhormone replacement therapy users were included in this study.
Anthropometric measurements of height, weight and waist and hip circumferences; dual energy X-ray absorptiometry measurements of total body fat; and computerized tomography measurements of abdominal adiposity were carried out.
Women in the exercise group exercised a mean of 3.6 days (s.d.=1.3) per week and 178.5 min (s.d.=76.1) per week. Changes in all measures of adiposity favored exercisers relative to controls (P<0.001). The mean difference between groups was: -1.8 kg for body weight; -2.0 kg for total body fat; -14.9 cm(2) for intra-abdominal fat area; and -24.1 cm(2) for subcutaneous abdominal fat area. A linear trend of greater body fat loss with increasing volume of exercise was also observed.
A 1-year aerobic exercise program consistent with current public health guidelines resulted in reduced adiposity levels in previously sedentary postmenopausal women at higher risk of breast cancer.
我们研究了有氧运动干预对肥胖相关结果的影响，这些结果可能与体力活动和乳腺癌风险之间的关联有关。
这是一项两中心、双臂、随机对照试验。为期一年的运动干预包括每周五次，每次 45 分钟的中等至剧烈有氧运动，其中至少有三次是在健身房进行的。对照组被要求不要改变他们的活动，两组都被要求不要改变他们的饮食。
共有 320 名绝经后、久坐不动、体重正常至肥胖的 50-74 岁女性，她们无癌症、非糖尿病和非激素替代疗法使用者，被纳入本研究。
身高、体重、腰围和臀围的人体测量学测量；全身脂肪的双能 X 射线吸收法测量；腹部肥胖的计算机断层扫描测量。
运动组的女性平均每周运动 3.6 天（标准差=1.3），每周运动 178.5 分钟（标准差=76.1）。与对照组相比，所有肥胖指标的变化都有利于锻炼者（P<0.001）。组间平均差异为：体重减少 1.8 公斤；全身脂肪减少 2.0 公斤；内脏脂肪面积减少 14.9 平方厘米；腹部皮下脂肪面积减少 24.1 平方厘米。还观察到随着运动量的增加，体脂减少量呈线性增加的趋势。
一项为期一年的符合当前公共卫生指南的有氧运动方案，使以前久坐不动的绝经后、乳腺癌风险较高的女性的肥胖水平降低。
