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Thiopurines in IBD: What Is Their Mechanism of Action?

作者信息

Neurath Markus

机构信息

Professor of Medicine Head of the Endoscopy Unit Johannes Gutenberg University of Mainz Mainz, Germany.

出版信息

Gastroenterol Hepatol (N Y). 2010 Jul;6(7):435-6.

PMID:20827366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2933759/
Abstract
摘要

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本文引用的文献

1
Understanding the delayed onset of action of azathioprine in IBD: are we there yet?理解硫唑嘌呤在炎症性肠病中的延迟起效：我们做到了吗？
Gut. 2009 Mar;58(3):325-6. doi: 10.1136/gut.2008.163485.
2
Early preservation of effector functions followed by eventual T cell memory depletion: a model for the delayed onset of the effect of thiopurines.早期效应功能的保留随后是最终T细胞记忆的耗竭：硫嘌呤类药物效应延迟出现的一种模型。
Gut. 2009 Mar;58(3):396-403. doi: 10.1136/gut.2008.157339. Epub 2008 Oct 2.
3
Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins.硫唑嘌呤通过抑制Rac蛋白上的Vav鸟苷交换活性，抑制埃兹蛋白-根蛋白-膜突蛋白依赖性T细胞与抗原呈递细胞的结合。
J Immunol. 2006 Jan 1;176(1):640-51. doi: 10.4049/jimmunol.176.1.640.
4
CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes.CD28 依赖性 Rac1 激活是硫唑嘌呤在原代人 CD4+ T 淋巴细胞中的分子靶点。
J Clin Invest. 2003 Apr;111(8):1133-45. doi: 10.1172/JCI16432.
5
A history of immunosuppressive drugs in the treatment of inflammatory bowel disease: origins at the Mount Sinai Hospital.免疫抑制药物治疗炎症性肠病的历史：起源于西奈山医院。
Mt Sinai J Med. 1996 May-Sep;63(3-4):191-201.