Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom.
Curr Opin Cell Biol. 2010 Oct;22(5):690-6. doi: 10.1016/j.ceb.2010.08.020. Epub 2010 Sep 7.
Due to the use of intra-vital imaging techniques and assays for cell migration into 3D matrices there has recently been much interest in different modes of tumour cell migration. Individually moving tumour cells can move either in an elongated-protrusive manner or in rounded, so-called 'amoeboid' modes. This review summarises ongoing efforts to delineate the cell signalling pathways that underlie these different forms of movement.
由于使用了活体成像技术和细胞迁移到 3D 基质的测定方法，目前人们对不同类型的肿瘤细胞迁移方式产生了浓厚的兴趣。单个移动的肿瘤细胞可以以拉长伸出的方式或圆形的、所谓的“阿米巴样”方式移动。这篇综述总结了目前为阐明这些不同运动形式的细胞信号通路所做的努力。
