Cherniack E Paul
The Geriatrics Institute, University of Miami Miller School of Medicine, Division of Geriatrics and Gerontology, and the Geriatrics and Extended Care Service and Geriatric Research Education, and Clinical Center (GRECC) of the Miami Veterans Affairs Medical Center, Miami, FL, USA.
Forsch Komplementmed. 2010;17(4):181-7. doi: 10.1159/000319143. Epub 2010 Aug 3.
Cellular senescence is characterized by cellular hypertrophy: cell growth in the absence of cell division. The genes that regulate this process can be activated or inactivated by numerous plant polyphenols such as resveratrol, quercetin, butein, fistein, piceatannol, curcumin. Many of these substances have been shown to lengthen the lifespan of invertebrates. Many of these compounds have other potential beneficial effects on lifespan as antiatherogenic or antineoplastic agents. Challenges to human testing of such substances on lifespan include determination of dosage, low bioavailability, time and resources necessary to conduct tests, and understanding which formulation of substances to use.
即细胞在不进行细胞分裂的情况下生长。调节这一过程的基因可被多种植物多酚激活或失活，如白藜芦醇、槲皮素、紫铆因、染料木黄酮、白皮杉醇、姜黄素。这些物质中的许多已被证明可延长无脊椎动物的寿命。作为抗动脉粥样硬化或抗肿瘤药物，这些化合物中的许多对寿命还有其他潜在的有益影响。对这类物质进行人体寿命测试面临的挑战包括确定剂量、生物利用度低、进行测试所需的时间和资源，以及了解使用哪种物质制剂。
