致密乳腺组织作为乳腺癌的重要危险因素及其对早期检测的影响。
Dense Breast Tissue as an Important Risk Factor for Breast Cancer and Implications for Early Detection.
作者信息
Schreer Ingrid
机构信息
Mammazentrum Universitätsklinikum Schleswig-Holstein, Campus Kiel, Germany.
出版信息
Breast Care (Basel). 2009;4(2):89-92. doi: 10.1159/000211954. Epub 2009 Apr 24.
Abstract
More than 30 years ago, John Wolfe was the first to observe and describe the association between breast density on mammography and increased breast cancer risk. Following this pioneer work, there is now compelling evidence that density in the highest quartile represents a 4-6 times higher risk of breast cancer. This magnitude of risk is only topped by age and BRCA1/2 mutation. The density-based risk is independent of age and other risk factors. Apart from epidemiologic risk factors, additional genetic factors seem to influence density. This could be the reason behind the well-known interaction between genes and environment. Reliable and reproducible breast density measurements are a prerequisite for the use of breast density to monitor primary prevention strategies and for the use of mammographic density to define women at higher breast cancer risk who would benefit from intensified early detection and surveillance protocols.
摘要
30多年前，约翰·沃尔夫首次观察并描述了乳房X线摄影中乳腺密度与乳腺癌风险增加之间的关联。在这项开创性工作之后，现在有令人信服的证据表明，处于最高四分位数的密度代表患乳腺癌的风险高出4至6倍。这种风险程度仅次于年龄和BRCA1/2突变。基于密度的风险独立于年龄和其他风险因素。除了流行病学风险因素外，其他遗传因素似乎也会影响密度。这可能是基因与环境之间众所周知的相互作用背后的原因。可靠且可重复的乳腺密度测量是利用乳腺密度监测一级预防策略以及利用乳房X线摄影密度来确定乳腺癌风险较高、将从强化早期检测和监测方案中受益的女性的先决条件。
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