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基于深度卷积神经网络的乳腺病变 X 光图像分类。

Breast lesions classifications of mammographic images using a deep convolutional neural network-based approach.

机构信息

Faculty of Information Technology, Beijing University of Technology, Beijing, China.

Division of Science and Technology, Department of Information Sciences, University of Education, Lahore, Pakistan.

出版信息

PLoS One. 2022 Jan 27;17(1):e0263126. doi: 10.1371/journal.pone.0263126. eCollection 2022.

Abstract

Breast cancer is one of the worst illnesses, with a higher fatality rate among women globally. Breast cancer detection needs accurate mammography interpretation and analysis, which is challenging for radiologists owing to the intricate anatomy of the breast and low image quality. Advances in deep learning-based models have significantly improved breast lesions' detection, localization, risk assessment, and categorization. This study proposes a novel deep learning-based convolutional neural network (ConvNet) that significantly reduces human error in diagnosing breast malignancy tissues. Our methodology is most effective in eliciting task-specific features, as feature learning is coupled with classification tasks to achieve higher performance in automatically classifying the suspicious regions in mammograms as benign and malignant. To evaluate the model's validity, 322 raw mammogram images from Mammographic Image Analysis Society (MIAS) and 580 from Private datasets were obtained to extract in-depth features, the intensity of information, and the high likelihood of malignancy. Both datasets are magnificently improved through preprocessing, synthetic data augmentation, and transfer learning techniques to attain the distinctive combination of breast tumors. The experimental findings indicate that the proposed approach achieved remarkable training accuracy of 0.98, test accuracy of 0.97, high sensitivity of 0.99, and an AUC of 0.99 in classifying breast masses on mammograms. The developed model achieved promising performance that helps the clinician in the speedy computation of mammography, breast masses diagnosis, treatment planning, and follow-up of disease progression. Moreover, it has the immense potential over retrospective approaches in consistency feature extraction and precise lesions classification.

摘要

乳腺癌是最严重的疾病之一,在全球范围内女性的死亡率更高。乳腺癌的检测需要准确的乳房 X 线照相术解读和分析,由于乳房的复杂解剖结构和图像质量低,这对放射科医生来说具有挑战性。基于深度学习的模型的进步极大地提高了乳房病变的检测、定位、风险评估和分类。本研究提出了一种新的基于深度学习的卷积神经网络(ConvNet),可以大大减少诊断乳腺癌组织中人类的错误。我们的方法在提取特定于任务的特征方面最为有效,因为特征学习与分类任务相结合,可以在自动分类乳房 X 光片中的可疑区域为良性和恶性方面实现更高的性能。为了评估模型的有效性,从 Mammographic Image Analysis Society (MIAS) 获得了 322 张原始乳房 X 光图像和 580 张来自私人数据集的图像,以提取深度特征、信息强度和高度恶性的可能性。通过预处理、合成数据扩充和迁移学习技术,两个数据集都得到了极大的改善,以获得独特的乳房肿瘤组合。实验结果表明,所提出的方法在对乳房 X 光片中的乳房肿块进行分类方面实现了显著的训练准确率 0.98、测试准确率 0.97、高灵敏度 0.99 和 AUC 0.99。所开发的模型实现了有希望的性能,有助于临床医生快速计算乳房 X 光、乳房肿块诊断、治疗计划和疾病进展的随访。此外,它在一致性特征提取和精确病变分类方面具有巨大的潜力,超过了回顾性方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c35b/8794221/e990fbc736bf/pone.0263126.g001.jpg

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