School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahi-dai, Nomi, Ishikawa, 923-1292, Japan.
Chem Commun (Camb). 2010 Oct 28;46(40):7545-7. doi: 10.1039/c0cc03151h. Epub 2010 Sep 17.
Photo-induced artificial RNA editing was demonstrated using photo-reactive oligonucleotides containing 3-cyanovinylcarbazole nucleoside. This non-enzymatic and sequence-specific methodology will make a major contribution to the elucidation of RNA functions including non-coding RNAs and to the development of drugs based on sequence-specific RNA editing.
利用含有 3-氰基乙烯基咔唑核苷的光反应性寡核苷酸，证明了光诱导的人工 RNA 编辑。这种非酶促和序列特异性的方法将为阐明 RNA 功能（包括非编码 RNA）以及基于序列特异性 RNA 编辑的药物开发做出重大贡献。
