School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
J Gastroenterol. 2011 Feb;46(2):164-74. doi: 10.1007/s00535-010-0321-6. Epub 2010 Sep 17.
Post-infectious irritable bowel syndrome (PI-IBS) is a subset of IBS which occurs after an episode of acute gastrointestinal infections. The mechanisms of PI-IBS are not fully understood. Currently, numerous animal models have been used in the study of PI-IBS. This article reviews the strengths and weaknesses of these models.
All relevant articles were identified by searching in Ovid SP from 1962, the year the term PI-IBS was coined, up to December 31, 2009. The types of model were categorized as either post-infectious or post-inflammatory, and the characteristics of each kind of model were listed.
Based on our literature search, 268 articles were identified. Of those articles, 50 were included in this review. The existing PI-IBS models include infection with bacteria (e.g., Campylobacter jejuni, Salmonella enterica, and Campylobacter rodentium), and infection with parasites (e.g., Trichinella spiralis, Nippostrongylus brasiliensis, and Cryptosporidium parvum). The post-inflammatory IBS models are commonly induced with chemical agents, such as acetic acid, deoxycholic acid, dextran sulfate sodium, mustard oil, zymosan, and trinitrobenzene sulfonic acid (TNBS). TNBS is the most commonly used agent for post-inflammatory IBS models, but the experimental protocol varies. These models have one or more aspects similar to IBS patients.
Different methods have been used for the development of post-infectious or post-inflammatory IBS models. Each model has its weaknesses and strengths. More studies are needed to establish post-infection IBS models using more common pathogens. A standard protocol in developing TNBS-induced post-inflammatory IBS model is needed.
感染后肠易激综合征（PI-IBS）是肠易激综合征（IBS）的一个亚组，发生于急性胃肠道感染后。PI-IBS 的发病机制尚不完全清楚。目前，已有多种动物模型用于 PI-IBS 的研究。本文综述了这些模型的优缺点。
检索 Ovid SP 从 1962 年（PI-IBS 一词出现的年份）到 2009 年 12 月 31 日的所有相关文献。根据模型类型分为感染后和炎症后，并列出每种模型的特点。
根据文献检索，共鉴定出 268 篇文章。其中 50 篇被纳入本综述。现有的 PI-IBS 模型包括细菌感染（如空肠弯曲菌、肠炎沙门氏菌和鼠弯曲菌）和寄生虫感染（如旋毛虫、巴西钩虫和微小隐孢子虫）。炎症后 IBS 模型通常用化学试剂诱导，如乙酸、脱氧胆酸、葡聚糖硫酸钠、芥末油、酵母聚糖和三硝基苯磺酸（TNBS）。TNBS 是最常用于炎症后 IBS 模型的试剂，但实验方案有所不同。这些模型具有一个或多个与 IBS 患者相似的方面。
不同的方法已用于开发感染后或炎症后 IBS 模型。每种模型都有其优缺点。需要进一步的研究来建立更常见病原体感染后 IBS 模型。需要建立 TNBS 诱导炎症后 IBS 模型的标准方案。
