National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts 02130, USA.
Inflamm Bowel Dis. 2010 Dec;16(12):2158-61. doi: 10.1002/ibd.21298.
The risk of suicide is increased among people with inflammatory bowel disease (IBD); however, most of the evidence regarding this association comes from studies of all-cause mortality, with small numbers of people who have committed suicide, or from clinical case reports. The current study examined the association between the two forms of IBD: Crohn's disease (CD) and ulcerative colitis (UC), and completed suicide in a population-based sample.
Data for this nested case-control study were obtained from the Danish national healthcare and social registries. We included 27,053 cases who completed suicide between January 1, 1981, and December 31, 2006. Controls were selected from the general population and matched to cases on gender, date of birth, and calendar time (n = 551,060).
There was an increased rate of suicide among participants with both CD (odds ratio [OR] = 1.6, 95% confidence interval [CI]: 1.1, 2.3) and UC (OR = 1.9, 95% CI: 1.4, 2.4), when adjusting for the matched factors and identified confounders.
The current study suggests that physicians treating IBD patients should be vigilant about expressions of suicidal ideation or signs and symptoms of self-harm.
炎症性肠病（IBD）患者的自杀风险增加；然而，大多数关于这种关联的证据来自全因死亡率的研究，涉及自杀的人数较少，或者来自临床病例报告。本研究在基于人群的样本中检查了两种形式的 IBD（克罗恩病 [CD] 和溃疡性结肠炎 [UC]）与自杀之间的关联。
本嵌套病例对照研究的数据来自丹麦国家医疗保健和社会登记处。我们纳入了 1981 年 1 月 1 日至 2006 年 12 月 31 日期间自杀的 27,053 例病例。对照来自一般人群，并根据性别、出生日期和日历时间与病例相匹配（n = 551,060）。
在调整匹配因素和确定的混杂因素后，CD（优势比 [OR] = 1.6，95%置信区间 [CI]：1.1，2.3）和 UC（OR = 1.9，95% CI：1.4，2.4）患者的自杀率均升高。
本研究表明，治疗 IBD 患者的医生应警惕自杀意念或自残的迹象和症状。
