使用暴食动物模型研究食物成瘾。
The study of food addiction using animal models of binge eating.
机构信息
University of Florida, Department of Psychiatry, Gainesville, 32608, United States.
出版信息
Appetite. 2010 Dec;55(3):734-7. doi: 10.1016/j.appet.2010.09.010. Epub 2010 Sep 16.
Abstract
This review summarizes evidence of "food addiction" using animal models of binge eating. In our model of sucrose bingeing, behavioral components of addiction are demonstrated and related to neurochemical changes that also occur with addictive drugs. Evidence supports the hypothesis that rats can become dependent and "addicted" to sucrose. Results obtained when animals binge on other palatable foods, including a fat-rich food, are described and suggest that increased body weight can occur. However, the characterization of an addiction-like behavioral profile in animals with binge access to fat requires further exploration in order to dissociate the effect of increased body weight from the diet or schedule of feeding.
摘要
这篇综述总结了使用暴食动物模型来证明“食物成瘾”的证据。在我们的蔗糖暴食模型中，成瘾的行为成分得到了证明，并与成瘾药物也会发生的神经化学变化有关。有证据支持这样的假设，即大鼠可以对蔗糖产生依赖和“成瘾”。当动物暴食其他美味食物，包括高脂肪食物时，也会得到类似的结果，并表明体重会增加。然而，要将暴食高脂肪食物的动物的类似成瘾行为特征进行明确的描述，需要进一步探索，以便将体重增加的影响与饮食或进食时间区分开来。
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