Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Eur J Immunol. 2010 Aug;40(8):2094-8. doi: 10.1002/eji.201040602.
Plasmacytoid DC (pDC) secrete type I IFN in response to viruses and RNA/DNA/immunocomplexes. Type I IFN confer resistance to viral infections and promote innate and adaptive immune responses. pDC also produce cytokines and chemokines that influence recruitment and function of T cells and differentiation of B cells. Thus, pDC have been implicated both in protective immune responses and in induction of tolerance. In this Viewpoint, we discuss how the recruitment and accumulation of pDC may impact pathogenesis of several diseases and how pDC can be targeted for therapeutic interventions.
浆细胞样树突状细胞(pDC)在受到病毒、RNA/DNA/免疫复合物的刺激后会分泌 I 型干扰素。I 型干扰素赋予了细胞抵抗病毒感染的能力,并促进了固有免疫和适应性免疫应答。pDC 还会产生细胞因子和趋化因子,影响 T 细胞的募集和功能以及 B 细胞的分化。因此,pDC 既参与了保护性免疫应答,也参与了免疫耐受的诱导。在本观点中,我们讨论了 pDC 的募集和积累如何影响多种疾病的发病机制,以及如何针对 pDC 进行治疗干预。