Eastern New Mexico University, Department of Biology, Station 33, Portales, NM 88130, USA.
Antimicrob Agents Chemother. 2010 Dec;54(12):5406-12. doi: 10.1128/AAC.00580-10. Epub 2010 Sep 20.
A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold, was observed for linezolid and tetraphenylphosphonium chloride (TPCL), followed by an 8-fold increase for sodium dodecyl sulfate (SDS), trimethoprim, and chloramphenicol. LmrS has 14 predicted membrane-spanning domains and is homologous to putative lincomycin resistance proteins of Bacillus spp., Lactobacillus spp., and Listeria spp.
一个名为 LmrS（金黄色葡萄球菌的林可霉素抗性蛋白）的多药外排泵，属于转运体的主要易化子超家族（MFS），被克隆，并评估了 LmrS 在抗菌外排中的作用。林可霉素和四苯膦盐酸盐（TPCL）的 MIC 相对增加最高，为 16 倍，其次是十二烷基硫酸钠（SDS）、甲氧苄啶和氯霉素，增加了 8 倍。LmrS 有 14 个预测的跨膜结构域，与芽孢杆菌属、乳杆菌属和李斯特菌属的推定林可霉素抗性蛋白同源。
