Medical College of Wisconsin, 9200 West Wisconsin Avenue, FEC Suite E5100, Milwaukee, WI 53226, USA.
Curr Hypertens Rep. 2010 Dec;12(6):448-55. doi: 10.1007/s11906-010-0150-2.
Hypertension contributes significantly to worldwide cardiovascular morbidity and mortality. Hypertension appears to have a complex association with endothelial dysfunction, a phenotypical alteration of the vascular endothelium that precedes the development of adverse cardiovascular events and portends future cardiovascular risk. This review concentrates on recent findings with respect to the mechanisms of hypertension-associated endothelial dysfunction, the interrelationship between these two entities, and the relationship of the efficacy of antihypertensive therapies to improvements in vascular homeostasis beyond blood pressure reduction. Current evidence suggests that hypertension and endothelial dysfunction are integrally related with respect to pathophysiologic mechanisms. Future studies will need to identify the key connections between hypertension and endothelial dysfunction to allow novel interventions to be designed and promulgated.
高血压是导致全球心血管发病率和死亡率的主要因素之一。高血压似乎与内皮功能障碍有复杂的关联，后者是血管内皮的表型改变，发生在不良心血管事件发展之前，并预示着未来的心血管风险。这篇综述集中讨论了与高血压相关的内皮功能障碍的机制、这两个实体之间的相互关系以及降压以外的血管稳态改善与抗高血压治疗效果之间的关系。目前的证据表明，高血压和内皮功能障碍在病理生理机制上是密切相关的。未来的研究需要确定高血压和内皮功能障碍之间的关键联系，以便设计和推广新的干预措施。
