Nilsson G, Lindblom P, Ohlin M, Berling R, Vernersson E
Department of Anaesthesiology, General Hospital, Malmö, Sweden.
Drugs Exp Clin Res. 1990;16(6):307-14.
The pharmacokinetics of triglycyl-lysine-vasopressin (TGLVP) were studied in healthy male volunteers after single i.v. injections of 5, 10 and 20 micrograms/kg b. wt. The half-life of distribution and elimination was 8 and 50 min, respectively. The volume of distribution was 0.7 l/kg b.wt. and the plasma clearance 9 ml/kg b.wt./min. These values are different from those for arginine-vasopressin and lysine-vasopressin (LVP) but confirm to some extent earlier results on TGLVP. No dose-dependent changes of the pharmacokinetics of TGLVP were evident. The LVP formation after TGLVP is described in principle using a combination of pharmacokinetic and pharmacodynamic data. Therapeutically the results in this study suggest a 4-hour interval between injections.
在健康男性志愿者单次静脉注射5、10和20微克/千克体重的三甘氨酰赖氨酸加压素（TGLVP）后，对其药代动力学进行了研究。分布半衰期和消除半衰期分别为8分钟和50分钟。分布容积为0.7升/千克体重，血浆清除率为9毫升/千克体重/分钟。这些值与精氨酸加压素和赖氨酸加压素（LVP）的值不同，但在一定程度上证实了此前关于TGLVP的研究结果。TGLVP的药代动力学没有明显的剂量依赖性变化。原则上使用药代动力学和药效学数据的组合来描述TGLVP注射后的LVP形成。在治疗方面，本研究结果表明注射间隔为4小时。
