Department of Physics, Washington University, One Brookings Drive, Campus Box 1105, St. Louis, Missouri 63130, USA.
Phys Rev Lett. 2010 Jun 4;104(22):228102. doi: 10.1103/PhysRevLett.104.228102. Epub 2010 Jun 1.
The polymerization of actin via branching at a cell membrane containing nucleation-promoting factors is simulated using a stochastic-growth methodology. The polymerized-actin distribution displays three types of behavior: (a) traveling waves, (b) moving patches, and (c) random fluctuations. Increasing actin concentration causes a transition from patches to waves. The waves and patches move by a treadmilling mechanism not involving myosin II. The effects of downregulation of key proteins on actin wave behavior are evaluated.
使用一种随机增长方法模拟了在含有成核促进因子的细胞膜上通过分支进行的肌动蛋白聚合。聚合肌动蛋白的分布表现出三种行为：（a）传播波，（b）移动斑块，和（c）随机波动。增加肌动蛋白浓度会导致斑块向波的转变。波和斑块通过不涉及肌球蛋白 II 的踏车机制移动。评估了下调关键蛋白对肌动蛋白波行为的影响。
