雪旺细胞作为治疗周围神经病变的靶点。
Schwann cells as a therapeutic target for peripheral neuropathies.
机构信息
Department of Neurology, Johns Hopkins Hospital, 600 N. Wolfe St, 509 Pathology Building, Baltimore, MD 21287, USA.
出版信息
CNS Neurol Disord Drug Targets. 2010 Dec;9(6):801-6. doi: 10.2174/187152710793237412.
Abstract
Schwann cells, the myelin forming cells in the peripheral nervous system, play a key role in the pathology of various inflammatory, metabolic and hereditary polyneuropathies. Advances in identifying growth factors and signaling molecules that are expressed by Schwann cells have paved the way for development of new treatment strategies that are aimed to improve the protective and regenerative properties of Schwann cells in peripheral nerve disorders. These include the exogenous application of growth factors and neurohormones which have been advanced into clinical trials in humans, and transplantation paradigms that have been moved into late stage preclinical models. In this review we will discuss the latest developments in these therapeutic approaches with special regard to peripheral nerve disorders, in which progress in basic research has already been translated into clinical trials, including HIV-associated distal sensory polyneuropathy and diabetic neuropathy.
摘要
许旺细胞（Schwann cells）是周围神经系统中形成髓鞘的细胞，在各种炎症性、代谢性和遗传性多发性神经病的病理学中起着关键作用。在鉴定许旺细胞表达的生长因子和信号分子方面的进展，为开发新的治疗策略铺平了道路，这些策略旨在改善周围神经疾病中许旺细胞的保护和再生特性。这些策略包括外源性应用生长因子和神经激素，这些因子已经进入人体临床试验，以及移植范例已经进入后期临床前模型。在这篇综述中，我们将讨论这些治疗方法的最新进展，特别是在周围神经疾病方面，基础研究的进展已经转化为临床试验，包括 HIV 相关的远端感觉多发性神经病和糖尿病性神经病。
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PLoS Med. 2009 Feb 17;6(2):e1000029. doi: 10.1371/journal.pmed.1000029.
2
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Neurotherapeutics. 2008 Oct;5(4):507-15. doi: 10.1016/j.nurt.2008.07.001.
3
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Glia. 2009 Apr 1;57(5):479-89. doi: 10.1002/glia.20774.
4
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