Department of Human Nutritional Sciences, Richardson Centre for Functional Foods and Nutraceuticals, 196 Innovation Drive, University of Manitoba, Winnipeg, MB, Canada R3T 6C5.
Br J Nutr. 2011 Feb;105(3):417-27. doi: 10.1017/S0007114510003697. Epub 2010 Sep 29.
Recently, novel dietary oils with modified fatty acid profiles have been manufactured to improve fatty acid intakes and reduce CVD risk. Our objective was to evaluate the efficacy of novel high-oleic rapeseed (canola) oil (HOCO), alone or blended with flaxseed oil (FXCO), on circulating lipids and inflammatory biomarkers v. a typical Western diet (WD). Using a randomised, controlled, crossover trial, thirty-six hypercholesterolaemic subjects consumed three isoenergetic diets for 28 d each containing approximately 36% energy from fat, of which 70% was provided by HOCO, FXCO or WD. Dietary fat content of SFA, MUFA, PUFA n-6 and n-3 was 6, 23, 5, 1% energy for HOCO; 6, 16, 5, 7·5% energy for FXCO; 11·5, 16, 6, 0·5% energy for WD. After 28 d, compared with WD, LDL-cholesterol was reduced 15·1% (P < 0·001) with FXCO and 7·4% (P < 0·001) with HOCO. Total cholesterol (TC) was reduced 11% (P < 0·001) with FXCO and 3·5% (P = 0·002) with HOCO compared with WD. Endpoint TC differed between FXCO and HOCO (P < 0·05). FXCO consumption reduced HDL-cholesterol by 8·5% (P < 0·001) and LDL:HDL ratio by 7·5% (P = 0·008) v. WD. FXCO significantly decreased E-selectin concentration compared with WD (P = 0·02). No differences were observed in inflammatory markers after the consumption of HOCO compared with WD. In conclusion, consumption of novel HOCO alone or when blended with flaxseed oil is cardioprotective through lipid-lowering effects. The incorporation of flaxseed oil may also target inflammation by reducing plasma E-selectin.
最近，人们制造了具有改良脂肪酸谱的新型食用油，以改善脂肪酸的摄入并降低 CVD 风险。我们的目的是评估新型高油酸油菜籽油（菜籽油）（HOCO）单独使用或与亚麻籽油（FXCO）混合使用对循环脂质和炎症生物标志物的功效，与典型的西方饮食（WD）相比。使用随机、对照、交叉试验，36 名高胆固醇血症患者每种饮食各消耗 28 天，三种饮食的能量均来自脂肪，约 36%，其中 70%由 HOCO、FXCO 或 WD 提供。HOCO 的 SFA、MUFA、PUFA n-6 和 n-3 的脂肪含量分别为 6、23、5、1%；FXCO 的脂肪含量分别为 6、16、5、7·5%；WD 的脂肪含量分别为 11·5、16、6、0·5%。与 WD 相比，28 天后，与 WD 相比，LDL-胆固醇降低了 15·1%（P < 0·001），而 FXCO 降低了 7·4%（P < 0·001）。与 WD 相比，TC 降低了 11%（P < 0·001），而 HOCO 降低了 3·5%（P = 0·002）。与 FXCO 相比，终点 TC 存在差异（P < 0·05）。与 WD 相比，FXCO 降低了 8·5%（P < 0·001）和 LDL:HDL 比值降低了 7·5%（P = 0·008）。与 WD 相比，FXCO 显著降低了 E-选择素浓度（P = 0·02）。与 WD 相比，HOCO 消费后炎症标志物无差异。总之，单独食用新型 HOCO 或与亚麻籽油混合食用具有心脏保护作用，可通过降低血脂发挥作用。加入亚麻籽油还可以通过降低血浆 E-选择素来靶向炎症。
