Wang Qiong, Zhang Hui, Jin Qingzhe, Wang Xingguo
State Key Lab of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Foods. 2023 Aug 9;12(16):3005. doi: 10.3390/foods12163005.
This meta-analysis aimed to investigate the impact of low-ratio linoleic acid/alpha-linolenic acid (LA/ALA) supplementation on the blood lipid profiles in adults. We conducted a systematic search for relevant randomized controlled trials (RCTs) assessing the effects of low-ratio LA/ALA using databases including PubMed, Embase, Cochrane, and Web of Science, as well as screened related references up until February 2023. The intervention effects were analyzed adopting weighted mean difference (WMD) and 95% confidence interval (CI). The meta-analysis indicated that low-ratio LA/ALA supplementation decreased total cholesterol (TC, WMD: -0.09 mmol/L, 95% CI: -0.17, -0.01, = 0.031, I = 33.2%), low-density lipoprotein cholesterol (LDL-C, WMD: -0.08 mmol/L, 95% CI: -0.13, -0.02, = 0.007, I = 0.0%), and triglycerides (TG, WMD: -0.05 mmol/L, 95% CI: -0.09, 0.00, = 0.049, I = 0.0%) concentrations. There was no significant effect on high-density lipoprotein cholesterol concentration (HDL-C, WMD: -0.00 mmol/L, 95% CI: -0.02, 0.02, = 0.895, I = 0.0%). Subgroup analysis showed that low-ratio LA/ALA supplementation significantly decreased plasma TC, LDL-C, and TG concentrations when the intervention period was less than 12 weeks. In the subgroup analysis, a noteworthy decrease in both TC and LDL-C levels was observed in individuals receiving low-ratio LA/ALA supplementation in the range of 1-5. These findings suggest that this specific range could potentially be effective in reducing lipid profiles. The findings of this study provide additional evidence supporting the potential role of low-ratio LA/ALA supplementation in reducing TC, LDL-C, and TG concentrations, although no significant impact on HDL-C was observed.
这项荟萃分析旨在研究低比例亚油酸/α-亚麻酸（LA/ALA）补充剂对成年人血脂谱的影响。我们通过系统检索评估低比例LA/ALA效果的相关随机对照试验（RCT），检索数据库包括PubMed、Embase、Cochrane和Web of Science，并筛选截至2023年2月的相关参考文献。采用加权平均差（WMD）和95%置信区间（CI）分析干预效果。荟萃分析表明，低比例LA/ALA补充剂可降低总胆固醇（TC，WMD：-0.09 mmol/L，95% CI：-0.17，-0.01，P = 0.031，I² = 33.2%）、低密度脂蛋白胆固醇（LDL-C，WMD：-0.08 mmol/L，95% CI：-0.13，-0.02，P = 0.007，I² = 0.0%）和甘油三酯（TG，WMD：-0.05 mmol/L，95% CI：-0.09，0.00，P = 0.049，I² = 0.0%）的浓度。对高密度脂蛋白胆固醇浓度（HDL-C，WMD：-0.00 mmol/L，95% CI：-0.02，0.02，P = 0.895，I² = 0.0%）无显著影响。亚组分析显示，当干预期小于12周时，低比例LA/ALA补充剂可显著降低血浆TC、LDL-C和TG浓度。在亚组分析中，接受1-5范围内低比例LA/ALA补充剂的个体的TC和LDL-C水平均有显著下降。这些发现表明，这一特定范围可能对降低血脂谱有效。本研究结果提供了额外证据，支持低比例LA/ALA补充剂在降低TC、LDL-C和TG浓度方面的潜在作用，尽管未观察到对HDL-C有显著影响。
