青蒿琥酯滥用与来自非洲旅行者的恶性疟原虫疟疾。
Artesunate misuse and Plasmodium falciparum malaria in traveler returning from Africa.
机构信息
University of Toronto, Toronto, Ontario, Canada.
出版信息
Emerg Infect Dis. 2010 Oct;16(10):1608-10. doi: 10.3201/eid1610.100116.
Abstract
Plasmodium falciparum malaria developed in an African-born traveler who returned to Canada after visiting Nigeria. While there, she took artesunate prophylactically. Isolates had an elevated 50% inhibitory concentration to artemisinin, artesunate, and artemether, compared with that of other African isolates. Inappropriate use of artemisinin derivatives can reduce P. falciparum susceptibility.
摘要
一名在尼日利亚旅行后返回加拿大的非洲出生旅客患上了恶性疟原虫疟疾。在尼日利亚期间，她预防性地服用了青蒿琥酯。与其他非洲分离株相比，这些分离株对青蒿素、青蒿琥酯和蒿甲醚的 50%抑制浓度升高。青蒿素衍生物的不当使用会降低恶性疟原虫的敏感性。
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