异黄酮——作用机制及其对乳腺癌风险的影响
Isoflavones - Mechanism of Action and Impact on Breast Cancer Risk.
作者信息
Stubert Johannes, Gerber Bernd
机构信息
Department of Obstetrics and Gynecology, University of Rostock, Germany.
出版信息
Breast Care (Basel). 2009;4(1):22-29. doi: 10.1159/000200980. Epub 2009 Feb 20.
Abstract
Isoflavones are plant-derived substances with weak es-trogenic effects. Asian populations are high consumers of soy products which are rich in isoflavones. The lower breast cancer incidence in Asian women compared with Western women has been associated with the possibility of a preventive isoflavone effect on cancer risk. The aim of this review is to give an overview of current research data on the influence of isoflavones on the risk of primary breast cancer development as well as the risk of recurrence in breast cancer patients. Despite inconsistencies in the available data, an inverse correlation between isoflavone intake and risk of breast cancer is likely. However, a negative impact on breast cancer disease, especially on hormone receptor-positive tumors, cannot be excluded at present.
摘要
异黄酮是具有弱雌激素效应的植物衍生物质。亚洲人群大量食用富含异黄酮的豆制品。与西方女性相比，亚洲女性较低的乳腺癌发病率可能与异黄酮对癌症风险的预防作用有关。本综述的目的是概述当前关于异黄酮对原发性乳腺癌发生风险以及乳腺癌患者复发风险影响的研究数据。尽管现有数据存在不一致之处，但异黄酮摄入量与乳腺癌风险之间可能存在负相关。然而，目前不能排除异黄酮对乳腺癌疾病，尤其是激素受体阳性肿瘤有负面影响。
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