Henikoff S
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA.
Trends Genet. 1990 Dec;6(12):422-6. doi: 10.1016/0168-9525(90)90304-o.
Position-effect variegation in Drosophila--the mosaic expression of a gene placed adjacent to a junction between euchromatin and heterochromatin--remains an enigma. However, new insights are being gained from recent studies of genetic modifiers, new model systems, and variegating genes showing exceptional behavior.
果蝇中的位置效应斑驳现象——即一个基因镶嵌表达,该基因位于常染色质与异染色质交界处附近——仍然是一个谜。然而,最近对遗传修饰因子、新模型系统以及表现出异常行为的斑驳基因的研究正在带来新的见解。