宿主对多阶段病原体反应的模型。
A model of host response to a multi-stage pathogen.
作者信息
Delgado-Eckert Edgar, Shapiro Michael
机构信息
Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, 4058, Basel, Switzerland.
出版信息
J Math Biol. 2011 Aug;63(2):201-27. doi: 10.1007/s00285-010-0365-5. Epub 2010 Oct 2.
Abstract
We model the immune surveillance of a pathogen which passes through n immunologically distinct stages. The biological parameters of this system induce a partial order on the stages, and this, in turn, determines which stages will be subject to immune regulation. This corresponds to the system's unique asymptotically stable fixed point.
摘要
我们对一种病原体的免疫监视进行建模，该病原体经历n个免疫上不同的阶段。该系统的生物学参数在这些阶段上诱导出一个偏序，进而决定哪些阶段将受到免疫调节。这对应于该系统唯一的渐近稳定不动点。
相似文献
1
A model of host response to a multi-stage pathogen.宿主对多阶段病原体反应的模型。
J Math Biol. 2011 Aug;63(2):201-27. doi: 10.1007/s00285-010-0365-5. Epub 2010 Oct 2.
2
Regulation of the Macroautophagic Machinery, Cellular Differentiation, and Immune Responses by Human Oncogenic γ-Herpesviruses.人类致癌 γ 疱疹病毒对巨自噬机制、细胞分化和免疫反应的调控。
Viruses. 2021 May 8;13(5):859. doi: 10.3390/v13050859.
3
[Regulation and evasion of host immune responses by Epstein-Barr virus].[爱泼斯坦-巴尔病毒对宿主免疫反应的调控与逃避]
Wei Sheng Wu Xue Bao. 2016 Jan 4;56(1):19-25.
4
The long-lasting love affair between the budding yeast Saccharomyces cerevisiae and the Epstein-Barr virus.出芽酵母酿酒酵母与爱泼斯坦-巴尔病毒之间的长期“恋情”。
Biotechnol J. 2015 Sep;10(11):1670-81. doi: 10.1002/biot.201500161. Epub 2015 Aug 27.
5
Generation and Analysis of Humanized Mouse Model of EBV Infection.EBV感染人源化小鼠模型的构建与分析
Methods Mol Biol. 2017;1532:241-254. doi: 10.1007/978-1-4939-6655-4_18.
6
Research landmarks on the 60th anniversary of Epstein-Barr virus.爱泼斯坦-巴尔病毒发现60周年的研究里程碑。
Sci China Life Sci. 2025 Feb;68(2):354-380. doi: 10.1007/s11427-024-2766-0. Epub 2024 Nov 4.
7
CD8+ T cells far predominate over CD4+ T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell lines.
Blood. 2012 Dec 13;120(25):5085-7. doi: 10.1182/blood-2012-06-437285.
8
Mice with Reconstituted Human Immune System Components as a Tool to Study Immune Cell Interactions in EBV Infection.具有重组人类免疫系统成分的小鼠作为研究EB病毒感染中免疫细胞相互作用的工具
Methods Mol Biol. 2017;1532:229-240. doi: 10.1007/978-1-4939-6655-4_17.
9
Loss of T-Cell Multifunctionality and TCR-Vβ Repertoire Against Epstein-Barr Virus Is Associated With Worse Prognosis and Clinical Parameters in HIV Patients.T 细胞多功能性和针对 EBV 的 TCR-Vβ repertoire 的丧失与 HIV 患者的预后和临床参数较差相关。
Front Immunol. 2018 Oct 4;9:2291. doi: 10.3389/fimmu.2018.02291. eCollection 2018.
10
The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?病毒在多发性硬化症中的神秘作用：分子模拟还是免疫监视紊乱？
Trends Immunol. 2017 Jul;38(7):498-512. doi: 10.1016/j.it.2017.04.006. Epub 2017 May 23.
引用本文的文献
1
EBV Persistence--Introducing the Virus.EB病毒的持续存在——病毒介绍
Curr Top Microbiol Immunol. 2015;390(Pt 1):151-209. doi: 10.1007/978-3-319-22822-8_8.
2
The cycle of EBV infection explains persistence, the sizes of the infected cell populations and which come under CTL regulation.EBV 感染的循环解释了持续性、受感染细胞群体的大小以及受 CTL 调节的群体。
PLoS Pathog. 2013;9(10):e1003685. doi: 10.1371/journal.ppat.1003685. Epub 2013 Oct 17.
3
The pathogenesis of Epstein-Barr virus persistent infection.EB 病毒持续感染的发病机制。
Curr Opin Virol. 2013 Jun;3(3):227-32. doi: 10.1016/j.coviro.2013.04.005. Epub 2013 May 15.
本文引用的文献
1
The dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral output.EB病毒脱落的动态变化表明上皮细胞在扩大病毒输出方面起着核心作用。
PLoS Pathog. 2009 Jul;5(7):e1000496. doi: 10.1371/journal.ppat.1000496. Epub 2009 Jul 3.
2
Epstein-Barr virus: a paradigm for persistent infection - for real and in virtual reality.爱泼斯坦-巴尔病毒：持续性感染的范例——现实与虚拟现实中的情况
Trends Immunol. 2008 Apr;29(4):195-201. doi: 10.1016/j.it.2008.01.006. Epub 2008 Mar 6.
3
Perspectives on the basic reproductive ratio.关于基本繁殖数的观点。
J R Soc Interface. 2005 Sep 22;2(4):281-93. doi: 10.1098/rsif.2005.0042.
4
Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells.潜伏感染爱泼斯坦-巴尔病毒的外周B细胞表现出经典抗原选择记忆B细胞的分子特征。
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18093-8. doi: 10.1073/pnas.0509311102. Epub 2005 Dec 5.
5
Malaria.疟疾
Lancet. 2005;365(9469):1487-98. doi: 10.1016/S0140-6736(05)66420-3.
6
Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo.终末分化为浆细胞启动了爱泼斯坦-巴尔病毒在体内的复制周期。
J Virol. 2005 Jan;79(2):1296-307. doi: 10.1128/JVI.79.2.1296-1307.2005.
7
Acute infection with Epstein-Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells.爱泼斯坦-巴尔病毒的急性感染以静止的、潜伏感染的细胞为目标，使外周记忆B细胞区室不堪重负。
J Virol. 2004 May;78(10):5194-204. doi: 10.1128/jvi.78.10.5194-5204.2004.
8
Persistence of the Epstein-Barr virus and the origins of associated lymphomas.爱泼斯坦-巴尔病毒的持续存在与相关淋巴瘤的起源
N Engl J Med. 2004 Mar 25;350(13):1328-37. doi: 10.1056/NEJMra032015.
9
Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo.体内潜伏感染记忆细胞分裂时伯基特淋巴瘤爱泼斯坦-巴尔病毒表型的显示
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):239-44. doi: 10.1073/pnas.2237267100. Epub 2003 Dec 19.
10
The transmission of infectious mononucleosis.传染性单核细胞增多症的传播
Am J Med Sci. 1955 Mar;229(3):262-72. doi: 10.1097/00000441-195503000-00003.
Zotero 插件