Laboratory of Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.
Viruses. 2021 May 8;13(5):859. doi: 10.3390/v13050859.
The human γ-herpesviruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) encode oncogenes for B cell transformation but are carried by most infected individuals without symptoms. For this purpose, they manipulate the anti-apoptotic pathway macroautophagy, cellular proliferation and apoptosis, as well as immune recognition. The mechanisms and functional relevance of these manipulations are discussed in this review. They allow both viruses to strike the balance between efficient persistence and dissemination in their human hosts without ever being cleared after infection and avoiding pathologies in most of their carriers.
人类 γ 疱疹病毒 EBV（Epstein-Barr 病毒）和 KSHV（卡波西肉瘤相关疱疹病毒）编码 B 细胞转化的癌基因，但大多数受感染个体无症状携带。为此，它们操纵抗细胞凋亡途径自噬、细胞增殖和凋亡以及免疫识别。本文讨论了这些操作的机制和功能相关性。这些机制使两种病毒能够在不被清除的情况下，在其人类宿主中保持有效的持久性和传播性之间取得平衡，并避免大多数携带者出现病理。
