钯催化仲三氟甲基化烷基溴的Heck型反应。
Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides.
作者信息
Fan Tao, Meng Wei-Dong, Zhang Xingang
机构信息
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
出版信息
Beilstein J Org Chem. 2017 Dec 6;13:2610-2616. doi: 10.3762/bjoc.13.258. eCollection 2017.
An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction.
已开发出一种高效的钯催化仲三氟甲基化烷基溴的Heck型反应。该反应在温和的反应条件下进行，具有高效率和出色的官能团耐受性，甚至对甲酰基和羟基也是如此。初步机理研究表明，仲三氟甲基化烷基自由基参与了该反应。
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