Heald C L, Ritchie M R, Bolton-Smith C, Morton M S, Alexander F E
Public Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh, EH8 9AG, UK.
Br J Nutr. 2007 Aug;98(2):388-96. doi: 10.1017/S0007114507700703. Epub 2007 Apr 3.
A population-based case-control study of diet, inherited susceptibility and prostate cancer was undertaken in the lowlands and central belt of Scotland to investigate the effect of phyto-oestrogen intake and serum concentrations on prostate cancer risk. A total of 433 cases and 483 controls aged 50-74 years were asked to complete a validated FFQ and provide a non-fasting blood sample. Multivariate logistic regression analysis found significant inverse associations with increased serum concentrations of enterolactone (adjusted OR 0.40, 95 % CI 0.22, 0.71] and with the consumption of soy foods (adjusted OR 0.52, 95 % CI 0.30, 0.91). However, no significant associations were observed for isoflavone intake or serum genistein, daidzein and equol. This study supports the hypotheses that soy foods and enterolactone metabolised from dietary lignans protect against prostate cancer in older Scottish men.
在苏格兰低地和中部地区开展了一项基于人群的饮食、遗传易感性与前列腺癌的病例对照研究，以调查植物雌激素摄入量和血清浓度对前列腺癌风险的影响。共有433例年龄在50 - 74岁的病例和483例对照被要求完成一份经过验证的食物频率问卷（FFQ）并提供一份非空腹血样。多变量逻辑回归分析发现，血清肠内酯浓度升高存在显著的负相关（调整后的比值比为0.40，95%置信区间为0.22, 0.71），大豆食品的摄入量也存在显著负相关（调整后的比值比为0.52，95%置信区间为0.30, 0.91）。然而，异黄酮摄入量或血清染料木黄酮、大豆苷元和雌马酚未观察到显著相关性。本研究支持以下假设：大豆食品以及由膳食木脂素代谢生成的肠内酯可预防老年苏格兰男性患前列腺癌。
