School of Medicine, Unit of Primary Health Care, University of Eastern Finland, Kuopio, Finland.
Diabetes Care. 2011 Jan;34(1):71-6. doi: 10.2337/dc10-1044. Epub 2010 Oct 7.
To study the association between impaired glucose regulation (IGR), screen-detected type 2 diabetes, and previously known diabetes and depressive symptoms.
Altogether, 2,712 participants from three hospital districts in Finland attended a health examination. Cutoff scores ≥10 and ≥16 in the 21-item Beck Depression Inventory (BDI-21) were used for depressive symptoms. The participants were defined as having known diabetes if they reported diabetes. An oral glucose tolerance test was used to detect normal glucose regulation (NGR), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and screen-detected diabetes. The participants were defined as having IGR if they had IFG or IGT.
Prevalence of depressive symptoms, defined as a BDI-21 cutoff score ≥10, was 14.4% for those with NGR, 13.7% for those with IGR, 14.8% for those with screen-detected diabetes, and 26.4% for those with previously known diabetes. The corresponding prevalences for a cutoff score ≥16 were 3.4, 3.4, 4.2, and 7.5%, respectively. Compared with NGR and adjusted for demographic, lifestyle, and biological factors, the odds ratios for IGR, screen-detected diabetes, and previously known diabetes were 0.91 (95% CI 0.69-1.20), 0.70 (0.45-1.08), and 1.35 (0.84-2.15), respectively, for a cutoff score ≥10. For a cutoff score ≥16, the corresponding odds ratios were 1.05 (0.62-1.76), 0.87 (0.40-1.90), and 1.56 (0.69-3.50), respectively.
Participants with diagnosed diabetes had a higher prevalence of depressive symptoms than participants with NGR, IGR, and previously unknown diabetes. When potential confounding factors were included in the analysis, previously known diabetes was not significantly associated with depressive symptoms.
研究葡萄糖调节受损（IGR）、筛查发现的 2 型糖尿病和既往已知的糖尿病与抑郁症状之间的关系。
共有 2712 名来自芬兰三个医院区的参与者参加了健康检查。采用贝克抑郁量表（BDI-21）的 21 项得分≥10 和≥16 作为抑郁症状的临界值。如果参与者报告有糖尿病，则将其定义为患有已知糖尿病。采用口服葡萄糖耐量试验来检测正常血糖调节（NGR）、空腹血糖受损（IFG）、葡萄糖耐量受损（IGT）和筛查发现的糖尿病。如果参与者有 IFG 或 IGT，则将其定义为 IGR。
以 BDI-21 临界值≥10 为标准，无 IGR 的参与者的抑郁症状患病率为 14.4%，有 IGR 的参与者为 13.7%，筛查发现的糖尿病患者为 14.8%，而既往已知的糖尿病患者为 26.4%。以 BDI-21 临界值≥16 为标准，对应的患病率分别为 3.4%、3.4%、4.2%和 7.5%。与 NGR 相比，并在调整了人口统计学、生活方式和生物学因素后，IGR、筛查发现的糖尿病和既往已知的糖尿病的比值比分别为 0.91（95%CI 0.69-1.20）、0.70（0.45-1.08）和 1.35（0.84-2.15）。对于临界值≥10，相应的比值比为 1.05（0.62-1.76）、0.87（0.40-1.90）和 1.56（0.69-3.50）。
与 NGR、IGR 和既往未知的糖尿病患者相比，诊断为糖尿病的患者抑郁症状的患病率更高。当在分析中纳入潜在的混杂因素时，既往已知的糖尿病与抑郁症状之间无显著相关性。
