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呼气分析:医学与工程学之间的新界面。

Exhaled breath analysis: The new interface between medicine and engineering.

作者信息

Mashir Alquam, Dweik Raed A

机构信息

Department of Pathobiology/Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States.

出版信息

Adv Powder Technol. 2009 Sep;20(5):420-425. doi: 10.1016/j.apt.2009.05.003.

DOI:10.1016/j.apt.2009.05.003
PMID:20948990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2952965/
Abstract

Exhaled breath testing is becoming an increasingly important non-invasive diagnostic method that can be used in the evaluation of health and disease states in the lung and beyond. Potential advantages of breath tests over other conventional medical tests include their non-invasive nature, low cost, and safety. To advance in this area further, however, there has to be a close collaboration between technical experts and engineers who have devices looking for clinical application(s), the medical experts who have the clinical problems looking for a test/biomarker that can be helpful in diagnosis or monitoring, and industry/commercial experts who can build and commercialize the final product.

摘要

呼气测试正成为一种越来越重要的非侵入性诊断方法,可用于评估肺部及其他部位的健康和疾病状态。呼气测试相对于其他传统医学测试的潜在优势包括其非侵入性、低成本和安全性。然而,为了在这一领域取得进一步进展,寻求临床应用的设备技术专家和工程师、有临床问题并寻求有助于诊断或监测的测试/生物标志物的医学专家,以及能够制造并将最终产品商业化的行业/商业专家之间必须密切合作。

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本文引用的文献

1
Exhaled breath analysis: the new frontier in medical testing.呼气分析:医学检测的新前沿。
J Breath Res. 2008 Sep;2(3). doi: 10.1088/1752-7163/2/3/030301.
2
Biomarkers in exhaled breath condensate: a review of collection, processing and analysis.呼出气冷凝物中的生物标志物:采集、处理和分析综述。
J Breath Res. 2008 Sep;2(3):037004. doi: 10.1088/1752-7155/2/3/037004. Epub 2008 Sep 8.
3
Exhaled carbon monoxide as a new marker of respiratory diseases in children.呼出一氧化碳作为儿童呼吸道疾病的新标志物。
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:9-17.
4
A simple method for the trace determination of methanol, ethanol, acetone and pentane in human breath and in the ambient air by preconcentration on solid sorbents followed by gas chromatography.一种通过在固体吸附剂上预浓缩,然后进行气相色谱法来痕量测定人体呼出气体和环境空气中甲醇、乙醇、丙酮和戊烷的简单方法。
Talanta. 1997 Sep;44(9):1683-90. doi: 10.1016/s0039-9140(97)00073-8.
5
GC-MS analysis of breath odor compounds in liver patients.肝病患者呼出气味化合物的气相色谱-质谱联用分析
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 15;875(2):344-8. doi: 10.1016/j.jchromb.2008.08.031. Epub 2008 Sep 17.
6
Breath analysis in patients with end-stage renal disease: effect of haemodialysis.终末期肾病患者的呼吸分析:血液透析的影响
Eur J Clin Invest. 2008 Oct;38(10):728-33. doi: 10.1111/j.1365-2362.2008.02016.x.
7
Sub-parts per billion detection of trace volatile chemicals in human breath using selected ion flow tube mass spectrometry.使用选择离子流管质谱法对人体呼出气体中的痕量挥发性化学物质进行十亿分之一级别的检测。
BMC Res Notes. 2008 Jul 10;1:41. doi: 10.1186/1756-0500-1-41.
8
Cavity-enhanced optical frequency comb spectroscopy: application to human breath analysis.腔增强光学频率梳光谱学:在人体呼吸分析中的应用。
Opt Express. 2008 Feb 18;16(4):2387-97. doi: 10.1364/oe.16.002387.
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Exhaled nitric oxide in asthma. From diagnosis, to monitoring, to screening: are we there yet?哮喘中的呼出一氧化氮。从诊断到监测再到筛查:我们做到了吗?
Chest. 2008 Apr;133(4):837-9. doi: 10.1378/chest.07-2743.
10
New screening method for lung cancer by detecting volatile organic compounds in breath.通过检测呼出气体中的挥发性有机化合物筛查肺癌的新方法
Clin Transl Oncol. 2007 Jun;9(6):364-8. doi: 10.1007/s12094-007-0068-6.