Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan.
Qual Life Res. 2011 Apr;20(3):415-23. doi: 10.1007/s11136-010-9761-y. Epub 2010 Oct 17.
We explored covariates of the quality of life (QOL) in non-small-cell lung cancer (NSCLC) patients and made a comparison with healthy controls.
We assessed the QOL of 220 consecutive NSCLC patients at a university hospital. The QOL data were measured by the brief version of the World Health Organization's Quality of Life and by utility using the standard gamble method. We selected demographically matched healthy controls from the 2001 National Health Interview Survey for comparison. Multiple linear regression models were constructed to explore significant factors of QOL after controlling for covariates.
Patients with more advanced stages of NSCLC had poorer scores than did the healthy controls in the physical and psychological domains. Patients with disease duration of longer than 1 year tended to report higher physical and environment QOL than did those with NSCLC diagnosed for less than 1 year. Insight into one's own illness was associated with a higher utility, better social support, and improved financial resources.
QOL was significantly associated with staging and duration of NSCLC. Disease insight appears to be a positive factor for operable NSCLC patients of the Taiwanese culture, which implies that clinicians should respect patient autonomy in diagnosis disclosure.
我们探讨了非小细胞肺癌（NSCLC）患者生活质量（QOL）的相关因素，并与健康对照组进行了比较。
我们在一所大学医院评估了 220 例连续 NSCLC 患者的 QOL。QOL 数据通过世界卫生组织简明生活质量问卷和标准博弈法的效用测量进行评估。我们选择了 2001 年全国健康访谈调查中具有相同人口统计学特征的健康对照组进行比较。构建了多元线性回归模型，以控制协变量后探讨 QOL 的显著影响因素。
与健康对照组相比，NSCLC 晚期患者的身体和心理领域得分较差。疾病持续时间超过 1 年的患者比 NSCLC 诊断时间不足 1 年的患者报告身体和环境 QOL 更高。对自身疾病的了解与更高的效用、更好的社会支持和改善的经济资源相关。
QOL 与 NSCLC 的分期和持续时间显著相关。疾病认知似乎是台湾文化中可手术 NSCLC 患者的一个积极因素，这意味着临床医生在诊断披露时应尊重患者自主权。
