Marcheggiani F, Stella F, Battistelli S, Stocchi O, Troccoli R
Istituto di Istologia ed Analisi di Laboratorio, Università di Urbino.
Boll Soc Ital Biol Sper. 1990 Oct;66(10):921-8.
In order to show the accumulation of Cd, Pb, Cu and Zn in smokers, levels of these metals in serum were determined in 108 subjects: 32 non-smokers, 37 average cigarette smokers and 39 heavy cigarette smokers. The analysis was carried out by potentiometric stripping analysis (PSA) with the Tecator "Striptec System". Backward oxidation time of the amalgamated metals, by means of electrolysis, in a thin "film" of mercury in an electrode, gives their concentration measure. Our data showed an increase in average values of Cd and Pb in the serum of heavy smokers compared with average and non-smokers. Instead, as regards Cu and Zn, no differences were found in the two groups of smokers compared with the non-smokers used as controls. Results obtained of the Cd and Pb levels in serum are compatible with the presence of these metals in cigarette tobacco and inhaling them could contribute to disease connected with their accumulation in the human organism. For these subjects the increase in Cd values is of particular importance as it could predispose pulmonary emphysema.
为了显示吸烟者体内镉、铅、铜和锌的蓄积情况，对108名受试者的血清中这些金属的含量进行了测定：32名不吸烟者、37名普通吸烟者和39名重度吸烟者。采用Tecator“Striptec系统”通过电位溶出分析法（PSA）进行分析。通过电解，在电极中汞的薄“膜”中，汞齐化金属的反向氧化时间给出了它们的浓度测量值。我们的数据显示，与普通吸烟者和不吸烟者相比，重度吸烟者血清中镉和铅的平均值有所增加。相反，就铜和锌而言，与用作对照的不吸烟者相比，两组吸烟者中未发现差异。血清中镉和铅水平的结果与香烟烟草中存在这些金属相符，吸入这些金属可能导致与其在人体中蓄积相关的疾病。对于这些受试者来说，镉值的增加尤为重要，因为它可能诱发肺气肿。
