Department of Radiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.
Int J Cardiovasc Imaging. 2011 Jul;27(6):787-94. doi: 10.1007/s10554-010-9727-8. Epub 2010 Oct 23.
To assess the accuracy of (semi-)automatic measurements of left ventricular (LV) functional parameters in cardiac dual-source computed tomography (DSCT) compared to manually adjusted measurements in three different workstations. Forty patients, who underwent cardiac DSCT, were included (31 men, mean age 58 ± 14 years). Multiphase reconstructions were made with ten series at every 10% of the RR-interval. LV function analysis was performed on three different, commercially available workstations. On all three workstations, end-systolic volume (ESV), end-diastolic volume (EDV), LV ejection fraction (LVEF) and myocardial mass (MM) were calculated as automatically as possible. With the same DSCT datasets, LV functional parameters were also calculated with as many manual adjustments as needed for accurate assessment for all three software tools. For both semi-automatic as well as manual methods, time needed for evaluation was recorded. Paired t-tests were employed to calculate differences in LV functional parameters. Repeated measurements were performed to determine intra-observer and inter-observer variability. (Semi-)automatic measurements revealed a good correlation with manually adjusted measurements for Vitrea (LVEF r = 0.93, EDV r = 0.94, ESV r = 0.98 and MM r = 0.94) and Aquarius (LVEF r = 0.96, EDV r = 0.94, ESV r = 0.98 and MM r = 0.96). Also, good correlation was obtained for Circulation, except for LVEF (LVEF r = 0.45, EDV r = 0.93, ESV r = 0.92 and MM r = 0.86). However, statistically significant differences were found between (semi-)automatically and manually adjusted measurements for LVEF (P < 0.05) and ESV (P < 0.001) in Vitrea, all LV functional parameters in Circulation (P < 0.001) and EDV, ESV and MM (<0.001) in Aquarius Workstation. (Semi-)automatic measurement of LV functional parameters is feasible, but significant differences were found for at least two different functional parameters in all three workstations. Therefore, expert manual correction is recommended at all times.
评估心脏双源 CT（DSCT）中半自动测量左心室（LV）功能参数的准确性，并与三种不同工作站上手动调整测量结果进行比较。共纳入 40 例接受心脏 DSCT 的患者（男 31 例，平均年龄 58±14 岁）。在每个 RR 间期的 10%处进行多相位重建，在三种不同的商业可用工作站上进行 LV 功能分析。在所有三个工作站上，尽可能自动计算收缩末期容积（ESV）、舒张末期容积（EDV）、左心室射血分数（LVEF）和心肌质量（MM）。使用相同的 DSCT 数据集，还使用尽可能多的手动调整，对所有三种软件工具进行准确评估，计算 LV 功能参数。对于半自动和手动方法，记录评估所需的时间。使用配对 t 检验计算 LV 功能参数的差异。进行重复测量以确定观察者内和观察者间的可变性。半自动测量与手动调整测量结果具有良好的相关性，Vitrea 工作站的相关性为 LVEF（r=0.93）、EDV（r=0.94）、ESV（r=0.98）和 MM（r=0.94），Aquarius 工作站的相关性为 LVEF（r=0.96）、EDV（r=0.94）、ESV（r=0.98）和 MM（r=0.96）。Circulation 工作站除 LVEF 外（r=0.45），也具有良好的相关性，EDV（r=0.93）、ESV（r=0.92）和 MM（r=0.86）。然而，Vitrea 工作站的 LVEF（P<0.05）和 ESV（P<0.001）、Circulation 工作站的所有 LV 功能参数（P<0.001）以及 Aquarius 工作站的 EDV、ESV 和 MM（P<0.001），半自动和手动调整测量之间存在统计学差异。半自动测量 LV 功能参数是可行的，但在所有三个工作站上，至少有两个不同的功能参数存在显著差异。因此，建议始终进行专家手动校正。
