Muñoz Calvo B
Servicio de Medicina Interna, Hospital General de Lanzarote, Arrecife, Las Palmas.
Med Clin (Barc). 1990 Nov 10;95(16):601-4.
A patient with HBsAg-positive chronic aggressive hepatitis and HBeAg and hepatitis B virus DNA (HBV DNA) developed fatal Creutzfeldt-Jakob disease. The investigation of cerebrospinal fluid and a temporal lobe brain tissue post mortem sample with radioactive probes of previously cloned HBV DNA showed the unquestionable presence of viral nucleotide sequences in the nervous tissue (about 9 viral genomes per cell). Although a pathogenetic role in the underlying neurologic disease cannot be attributed to HBV, our observation widens the spectrum of tissues where HBV has been detected, and supports the contention that there are replicative extrahepatic foci where the immunologic system of the host is permissive for the virus.
一名乙肝表面抗原（HBsAg）阳性的慢性侵袭性肝炎患者，同时伴有e抗原（HBeAg）和乙肝病毒DNA（HBV DNA），发生了致命的克雅氏病。对脑脊液以及死后颞叶脑组织样本进行检测，使用先前克隆的HBV DNA放射性探针，结果显示神经组织中毫无疑问地存在病毒核苷酸序列（每个细胞约有9个病毒基因组）。虽然不能将潜在神经疾病的致病作用归因于乙肝病毒，但我们的观察拓宽了已检测到乙肝病毒的组织范围，并支持这样一种观点，即存在宿主免疫系统允许病毒复制的肝外复制灶。
