Department of Medicine, University of Leipzig, Leipzig, Germany.
Obes Facts. 2010 Oct;3(5):328-31. doi: 10.1159/000321637. Epub 2010 Oct 20.
Elevated visceral adipose tissue-derived serpin (vaspin) serum concentrations are associated with impaired insulin sensitivity, but increase unexpectedly after long-term physical training. We therefore investigated the effect of an acute exercise bout and the effects of vitamin supplementation on chronic exercise effect and on serum vaspin concentrations. We measured serum vaspin and thiobarbituric acid-reactive substances (TBARS) concentrations in 80 individuals before and after a 1-hour acute exercise bout and independently in 40 healthy young men who were randomly assigned to either antioxidant (vitamin C (1,000 mg/day) and vitamin E (400 IU/day)) or to no supplementation after a standardized 4-week physical training program as a post hoc analysis. Serum vaspin concentrations significantly decreased after acute physical exercise as well as after 4 weeks of training in individuals without antioxidants. Changes in vaspin serum concentration correlate with increased TBARS serum concentrations both in response to a 1-hour exercise bout (r = -0.42, p < 0.01) and to the 4-week training (r = -0.31, p < 0.05). Interestingly, supplementation with antioxidants rather increased circulating vaspin levels in response to 4 weeks of exercise. In conclusion, vaspin serum concentrations are decreased by exercise-induced oxidative stress, but not by exercise-associated improvement in insulin sensitivity.
内脏脂肪组织衍生丝氨酸蛋白酶抑制剂（vaspin）血清浓度升高与胰岛素敏感性受损有关，但在长期体育锻炼后会意外增加。因此，我们研究了急性运动对慢性运动效应和血清 vaspin 浓度的影响，以及维生素补充对它们的影响。我们在 1 小时急性运动后，测量了 80 名个体的血清 vaspin 和硫代巴比妥酸反应物质（TBARS）浓度，并对 40 名健康年轻男性进行了独立测量，这些男性在标准化 4 周体育训练后，随机分为抗氧化剂（维生素 C（1000mg/天）和维生素 E（400IU/天））或无补充组，这是作为事后分析进行的。在没有抗氧化剂的个体中，急性体力活动以及 4 周的训练后，血清 vaspin 浓度均显著降低。在对 1 小时运动的反应中（r = -0.42，p < 0.01）和 4 周的训练（r = -0.31，p < 0.05）中，血清 vaspin 浓度的变化与 TBARS 血清浓度的增加呈相关性。有趣的是，抗氧化剂补充剂在 4 周的运动后增加了循环 vaspin 水平。总之，运动引起的氧化应激会降低血清 vaspin 浓度，但不会改善胰岛素敏感性。
