Oo Khin May, Shimono Kunio, Koide Norio, Okada Shigeru
Department of Medical Research-Lower Myanmar, No.5 Ziwaka Road, Yangon, Myanmar.
Acta Med Okayama. 2010 Oct;64(5):317-21. doi: 10.18926/AMO/40507.
We studied the prevalence of hepatitis C virus infection among blood donors from 3 hospitals of Central Myanmar and 7 hospitals of Lower Myanmar in the Yangon area, and analyzed the factors associated with the infection. The study period was from November, 2005 to June, 2007. A pre-tested questionnaire was used to obtain information on age, ethnic group, marital status, tattooing, body piercing, history of receiving transfusions, and liver diseases in self and in sexual partners. Data on seropositivity to hepatitis C, hepatitis B and human immunodeficiency virus infections were recorded. A total of 65,240 blood donors participated in the study. Their ages ranged from 18 years to 60 years (mean±SD=29.5±9.3). The male-to-female ratio was 6:1. The prevalence of the antibody to hepatitis C was found to be 0.95% with varying rates (0.34 to 2.03) among hospitals. Females had a slightly higher rate (1.06%) than males (0.93%) (p=0.237). Multivariate analyses revealed the following factors to be related to HCV infection:HIV infection, odds ratio (OR)=3.0 (p=0.003); history of liver disease, OR=8.9 (p=0.001);and age 30 years and above, OR=2.6 (p=0.001). We discuss the varying prevalences of HCV around the world.
我们研究了缅甸中部3家医院及仰光地区下缅甸7家医院献血者中丙型肝炎病毒感染的流行情况，并分析了与感染相关的因素。研究期间为2005年11月至2007年6月。使用预先测试过的问卷获取有关年龄、种族、婚姻状况、纹身、穿孔、输血史以及自身和性伴侣的肝脏疾病等信息。记录丙型肝炎、乙型肝炎和人类免疫缺陷病毒感染的血清阳性数据。共有65240名献血者参与了该研究。他们的年龄在18岁至60岁之间（平均±标准差=29.5±9.3）。男女比例为6:1。丙型肝炎抗体的流行率为0.95%，各医院的流行率有所不同（0.34%至2.03%）。女性的流行率（1.06%）略高于男性（0.93%）（p=0.237）。多变量分析显示以下因素与丙型肝炎病毒感染有关：艾滋病毒感染，比值比（OR）=3.0（p=0.003）；肝脏疾病史，OR=8.9（p=0.001）；年龄30岁及以上，OR=2.6（p=0.001）。我们讨论了世界各地丙型肝炎病毒不同的流行情况。
