胱抑素C参考值与衰老
Cystatin C reference values and aging.
作者信息
Ognibene Agostino, Mannucci Edoardo, Caldini Anna, Terreni Alessandro, Brogi Marco, Bardini Gianluca, Sposato Iolanda, Mosconi Valentina, Salvadori Benedetta, Rotella Carlo Maria, Messeri Gianni
机构信息
Central Laboratory of Clinical Biochemistry, Careggi Hospital, Viale Morgagni 85, 50139 Florence, Italy.
出版信息
Clin Biochem. 2006 Jun;39(6):658-61. doi: 10.1016/j.clinbiochem.2006.03.017. Epub 2006 Apr 21.
OBJECTIVES
The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging.
DESIGN AND METHODS
The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected.
RESULTS
CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L).
CONCLUSIONS
The use of CysC reference values adjusted for age should be carefully taken into consideration.
目的
本研究旨在确定血清胱抑素C（CysC）的参考值，特别关注衰老的影响。
设计与方法
对一系列连续的受试者（258名男性和396名女性）进行了研究。收集了实验室参数以及详细的个人和家族病史。
结果
CysC在两性中均与年龄呈显著相关性，在调整血清肌酐（SCr）后通过多元线性回归得到证实。建立了与年龄相关的胱抑素C参考区间（<45岁，<0.95mg/L；>45岁，<1.20mg/L）。
结论
应谨慎考虑使用根据年龄调整的CysC参考值。
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