Department of Gastroenterology, Shanghai Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China.
World J Gastroenterol. 2010 Oct 28;16(40):5118-21. doi: 10.3748/wjg.v16.i40.5118.
To investigate the resistance of Helicobacter pylori (H. pylori) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai.
A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution.
The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone. The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients.
Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori-associated diseases.
研究 2000 年至 2009 年上海地区幽门螺杆菌（H. pylori）对 6 种常用抗生素的耐药性。
2000 年至 2009 年期间，从上海共收集 293 株 H. pylori 菌株，采用琼脂稀释法检测其对甲硝唑、克拉霉素、阿莫西林、呋喃唑酮、左氧氟沙星和四环素的敏感性。
2000 年至 2009 年，上海地区 H. pylori 对克拉霉素（8.6%、9.0%和 20.7%）和左氧氟沙星（10.3%、24.0%和 32.5%）的耐药率呈上升趋势。H. pylori 对甲硝唑的耐药率保持稳定（40%-50%）。2005 年分离的一株 H. pylori 对四环素耐药。所有菌株均对阿莫西林和呋喃唑酮敏感。H. pylori 对抗生素的耐药率与患者的性别、年龄和临床结局无关。
H. pylori 对抗生素的耐药性在制定针对 H. pylori 相关疾病的治疗策略中起着重要作用。
