Li Lei, Meng FanDong, Zhu Shengtao, Guo ShuiLong, Wang YongJun, Zhao Xin, Sun YiLin, Zhang Yan, Wang QinQin, Xu HuFeng, Zhang ShuTian
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, China.
Department of Digestive Diseases, Affiliated Hospital for Wei Fang Medical University, Wei Fang 261031, China.
Evid Based Complement Alternat Med. 2018 Feb 5;2018:4320219. doi: 10.1155/2018/4320219. eCollection 2018.
Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in -infected mouse model. We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats. We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules exhibited the highest efficacy of anti- activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti- activity and can be considered as an alternative to current bismuth compounds. Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other eradication medications in the clinical setting.
含铋四联疗法已被推荐作为克拉霉素或甲硝唑高耐药地区的一线治疗方案。然而，铋剂的安全性问题长期以来一直受到关注。我们首先在感染的小鼠模型中评估了胃铋美颗粒（一种由三种合成药物和五种草药组成的铋化合物）与铝酸铋和枸橼酸铋钾（CBS）相比的疗效和安全性。然后，我们使用原子荧光光谱法和自动金相显微镜来测量三种铋剂在成年Sprague-Dawley大鼠脑、心、肝和肾中的蓄积情况。我们还通过对实验动物的血液样本进行临床生化检测来评估铋剂的安全性。与CBS和铝酸铋相比，胃铋美颗粒表现出最高的抗活性疗效，且铋蓄积量最低。我们的研究结果表明，胃铋美颗粒是一种具有强效抗活性的安全中药，可被视为当前铋化合物的替代品。因此，胃铋美颗粒值得进一步评估，特别是在临床环境中与其他根除药物联合使用时的疗效和安全性方面。
