Passiu G, Sebastiani G D, Galeazzi M, Tuveri M A, Nicosia P M, Boirivant R
II Cattedra di Reumatologia, Università di Roma La Sapienza.
Medicina (Firenze). 1990 Oct-Dec;10(4):405-7.
Antinuclear antibodies (ANA) and nailfold capillary microscopy have been evaluated as prognostic markers in patients with apparently idiopathic Raynaud's phenomenon. Results have shown that either ANA and peculiar alterations in nailfold capillaries are important risk factors as regard to the evolution into a connective tissue disease; furthermore, when both these markers are present in a patient with Raynaud's phenomenon, the risk of evolution is even greater. When sensibility and specificity have been compared, ANA appeared to be a more sensible test but nailfold capillary microscopy seemed to be more specific. Our data suggest that ANA and capillary microscopy are important tests in patients with Raynaud's phenomenon; they should be performed in order to identify those patients who are at greater risk of evolving to overt connective tissue disease.
抗核抗体（ANA）和甲襞毛细血管显微镜检查已被评估为明显特发性雷诺现象患者的预后标志物。结果表明，ANA和甲襞毛细血管的特殊改变都是发展为结缔组织病的重要危险因素；此外，当这两种标志物同时出现在雷诺现象患者中时，病情进展的风险更大。在比较敏感性和特异性时，ANA似乎是一种更敏感的检测方法，但甲襞毛细血管显微镜检查似乎更具特异性。我们的数据表明，ANA和毛细血管显微镜检查对雷诺现象患者来说是重要的检测；应进行这些检查以识别那些发展为明显结缔组织病风险更高的患者。
