多溴联苯在孕期和哺乳期大鼠及其后代经饮食暴露后的分布情况。
Distribution of polybrominated biphenyls after dietary exposure in pregnant and lactating rats and their offspring.
作者信息
Rickert D E, Dent J G, Cagen S Z, McCormack K M, Melrose P, Gibson J E
出版信息
Environ Health Perspect. 1978 Apr;23:63-6. doi: 10.1289/ehp.782363.
Female rats were fed PBBs in the diet (50 ppm) from day 8 of gestation to day 21 of gestation, from day 1 postpartum to day 14 postpartum or from day 8 of gestation through day 14 postpartum. Levels of PBBs were measured in various tissues. Small concentrations of PBBs (less than 5 microgram/g) were found in the brain, heart, lung, liver, small intestine, placenta, and gravid uterus. Larger concentrations (less than 30 microgram/g) were found in kidneys, the nongravid uterus, skin, mammary tissue, and fat. Lactation did not significantly alter the concentrations of PBBs found in tissues other than mammary tissue. Offspring were subjected to several exposure regimens by cross-fostering. Concentrations of PBBs in the neonatal livers were higher than in the adults nursing them. Transfer of PBBs via the milk appears to be much more important to appearance of PBBs in newborns than does placental transfer.
从妊娠第8天至妊娠第21天、产后第1天至产后第14天或从妊娠第8天至产后第14天，给雌性大鼠喂食含多溴联苯（50 ppm）的饲料。测量了各种组织中的多溴联苯水平。在脑、心脏、肺、肝脏、小肠、胎盘和妊娠子宫中发现了低浓度的多溴联苯（低于5微克/克）。在肾脏、非妊娠子宫、皮肤、乳腺组织和脂肪中发现了较高浓度（低于30微克/克）。哺乳并未显著改变乳腺组织以外的其他组织中多溴联苯的浓度。通过交叉寄养使后代接受几种暴露方案。新生大鼠肝脏中的多溴联苯浓度高于哺育它们的成年大鼠。与胎盘转运相比，多溴联苯通过乳汁的转运对新生儿体内多溴联苯的出现似乎更为重要。
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