Hsiung G D, Choi Y C, Bia F
J Infect Dis. 1978 Aug;138(2):191-6. doi: 10.1093/infdis/138.2.191.
Studies on the pathogenesis of cytomegalovirus (CMV) infection in guinea pigs have revealed two distinct phases of infection, without any signs of clinical disease. During acute primary infection, viremia was easily demonstrated and infectious virus was recovered from various tissues, including lung, spleen, and kidney, of the infected animal two to 10 days after inoculation. Chronic persistent infection was readily established thereafter. In animals with chronic persistent infection with high levels of circulating antibody, infectious virus was consistently isolated from the salivary gland and pancreas. Evidence of CMV in the blood of the persistently infected animals was detected only occasionally and only when a highly sensitive method and/or a large inoculum was used. However, the anticoagulant heparin was found to inactivate CMV significantly during collection of blood. These data suggest that CMV was indeed circulating in the blood of apparently health but persistently infected animals for prolonged periods. Such infected blood could conceivably be the source of CMV infection when large quantities of blood are given to susceptible recipients.
对豚鼠巨细胞病毒（CMV）感染发病机制的研究揭示了感染的两个不同阶段，且无任何临床疾病迹象。在急性原发性感染期间，很容易证明存在病毒血症，并且在接种后两到十天从受感染动物的各种组织（包括肺、脾和肾）中回收了感染性病毒。此后很容易建立慢性持续性感染。在具有高水平循环抗体的慢性持续性感染动物中，始终从唾液腺和胰腺中分离出感染性病毒。仅在偶尔且仅当使用高度敏感的方法和/或大量接种物时，才在持续感染动物的血液中检测到CMV的证据。然而，发现抗凝剂肝素在采血过程中会使CMV显著失活。这些数据表明，CMV确实在表面健康但持续感染的动物血液中长时间循环。当向易感接受者输入大量血液时，这种受感染的血液可以想象是CMV感染的来源。
